SAB3500123

Monoclonal Anti-PD-1 antibody produced in mouse

clone 12A7D7, purified immunoglobulin, buffered aqueous solution

• Synonyme(s) : Anti-CD279, Anti-PDCD-1, Anti-Programmed cell death 1
• Numéro MDL: MFCD02095740
• Code UNSPSC : 12352203
• Nomenclature NACRES : NA.41

Propriétés

• Source biologique: mouse
• Conjugué: unconjugated
• Forme d'anticorps: purified immunoglobulin
• Type de produit anticorps: primary antibodies
• Clone: 12A7D7, monoclonal
• Forme: buffered aqueous solution
• Espèces réactives: rat, human, mouse
• Technique(s): immunohistochemistry: suitable; indirect ELISA: suitable; western blot: suitable
• Numéro d'accès UniProt: Q15116
• Conditions d'expédition: dry ice
• Température de stockage: −20°C
• Modification post-traductionnelle de la cible: unmodified
• Informations sur le gène: human ... PDCD1(5133)

Description

Description générale

Programmed death-1 (PD-1) is a type I transmembrane protein, encoded by the gene mapped to human chromosome 2q37.3. PD-1 belongs to the immunoglobulin receptor superfamily. The encoded protein is an immunoinhibitory receptor expressed by activated T cells, B cells, and myeloid cells. PD-1 is characterized with a single Ig-like variable (IgV) domain in the extracellular region and an immunoreceptor tyrosine-based inhibitory domain in the cytoplasmic region.

Immunogène

raised against an ~150 amino acid recombinant protein from near the terminus terminus of mouse PD-1.

Actions biochimiques/physiologiques

Programmed death-1 (PD-1) gene is sensitive to systemic lupus erythematosus (SLE). Polymorphisms in PD-1 may participate in the growth of EOC (epithelial ovarian cancer). It acts as a negative regulator of T cells. It is also responsible for immune escape mediated by tumor cells. Interaction of PD-1 and PD-L1 (ligand of PD-1) results in inhibition of T cell receptor–mediated lymphocyte proliferation and cytokine secretion.

Caractéristiques et avantages

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Description de la cible

Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antig en-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PDL-1 and PDL-2. Upon binding to either of these ligands, signals generated by PD-1 inhibit the activation of the immune response in the absence of "danger signals" such as LPS or other molecules associated with bacteria or other pathogens. Evidence for this is seen in PD1-null mice who exhibit hyperactivated immune systems and autoimmune diseases. Despite its predicted molecular weight, PD-1 often migrates at higher molecular weight in SDS-PAGE.

Forme physique

Supplied at approx. 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable