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Key Documents

SAB2701049

Sigma-Aldrich

Anti-CDT1 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonyme(s) :

CDT1, DUP, RIS2

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Espèces réactives

human

Technique(s)

immunohistochemistry: suitable
indirect immunofluorescence: suitable
western blot: 500-3000

Numéro d'accès NCBI

AAH08676

Numéro d'accès UniProt

Q9H211

Conditions d'expédition

wet ice

Température de stockage

−20°C

Informations sur le gène

human ... CDT1(81620)

Description générale

Chromatin licensing and DNA replication factor 1/Cdc10-dependent transcript 1 (CDT1), a G1-specific cell-cycle factor, belongs to the pre-replication complex (pre-RC). The CDT1 gene is located on the human chromosome 16q24.3.

Immunogène

Synthetic peptide containing a sequence corresponding to a region within amino acids 448 and 490 (Q9H211) of CDT1 according to AAH08676

Application

Suggested starting dilutions are as follows: ICC/IF: 1:100-1:1000, IHC-P: 1:100-1:1000, WB: 1:500-1:3000. Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the end user.

Actions biochimiques/physiologiques

Chromatin licensing and DNA replication factor 1/Cdc10-dependent transcript 1 (CDT1) is involved in minichromosome maintenance (MCM) loading at the G1 phase of the cell cycle. It plays a key role in origin licensing in eukaryotic cells. It is a DNA replication protein that stimulates the production of pre-replicative complexes and replication in the next cell cycle by accumulating at the end of the cell cycle. The CDT1 gene mutation can cause Meier–Gorlin syndrome, a type of primordial dwarfism.

Caractéristiques et avantages

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Forme physique

1XPBS, 20% Glycerol (pH7). 0.025% ProClin 300 was added as a preservative.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H317,H412

Classification des risques

Aquatic Chronic 3 - Skin Sens. 1

Code de la classe de stockage

12 - Non Combustible Liquids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

Andrea Ballabeni et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(30), E2848-E2853 (2013-07-10)
Cdc10-dependent transcript 1 (Cdt1) is an essential DNA replication protein whose accumulation at the end of the cell cycle promotes the formation of pre-replicative complexes and replication in the next cell cycle. Geminin is thought to be involved in licensing
Georgia Xouri et al.
Cell cycle (Georgetown, Tex.), 6(13), 1549-1552 (2007-06-30)
Within each cell cycle, a cell must ensure that the processes of selection of replication origins (licensing) and initiation of DNA replication are well coordinated to prevent reinitiation of DNA replication from the same DNA segment during the same cell
Zannel Blanchard et al.
PloS one, 9(4), e95663-e95663 (2014-05-03)
Breast cancer is the second leading cause of cancer-related deaths in women. Triple negative breast cancer (TNBC) is an aggressive subtype that affects 10-25% mostly African American women. TNBC has the poorest prognosis of all subtypes with rapid progression leading

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