RAB0711

Human CSF1R / Macrophage Colony-stimulating Factor 1 Receptor ELISA Kit

• Code UNSPSC : 41116158
• Nomenclature NACRES : NA.84

Propriétés

• Espèces réactives: human
• Conditionnement: kit of 96 wells (12 strips x 8 wells)
• Technique(s): ELISA: suitable
• assay range: inter-assay cv: <10%; intra-assay cv: <12%
• Méthode de détection: colorimetric
• Conditions d'expédition: wet ice
• Température de stockage: −20°C
• Informations sur le gène: human ... CSF1R(1436)

Description

Description générale

CSF1R (colony stimulating factor 1 receptor) is a member of the platelet-derived growth factor (PDGF) family of proteins and is a type III RTK (receptor tyrosine kinase). CSF1R is composed of five immunoglobulin (Ig)-like domains, a transmembrane region, a juxtamembrane domain and kinase insert domain (KID) intersecting the kinase domain.

The antibody pair provided in this kit recognizes human Macrophage Colony-stimulating Factor 1 Receptor.

Application

For research use only. Not for use in diagnostic procedures.
Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)

Actions biochimiques/physiologiques

CSF1R (colony stimulating factor 1 receptor) acts as a receptor for CSF1 and regulates monocyte and macrophage functioning. The protein and its ligand are linked to poor prognosis in patients with solid tumors and in patients with female reproductive cancers. In breast cancers, with decreased claudin levels, this protein regulates the switch between proliferative and invasive state of the tumor, acting downstream of TGFβ (tumor growth factor β). Haploinsufficiency in this receptor might lead to aberration of microglial function, which might be a contributor to the pathogenesis of hereditary diffuse leukoencephalopathy with spheroids (HDLS).

Composants de kit également disponibles séparément

• RABTMB3 ELISA Colorimetric TMB Reagent (HRP Substrate, Item H)
• RABSTOP3 ELISA Stop Solution (Item I)
• RABWASH4 20X Wash Buffer (Item B)

Informations sur la sécurité

• Pictogrammes: GHS05
• Mention d'avertissement: Warning
• Mentions de danger: H290
• Conseils de prudence: P234 - P390
• Classification des risques: Met. Corr. 1
• Code de la classe de stockage: 8A - Combustible corrosive hazardous materials
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable