R3905

Ro273225 trifluoroacetate salt

≥98% (reversed phase HPLC)

• Synonyme(s) : Butir-His-D-Phe-Arg-Trp-Sar-NH2 trifluoroacetate salt
• Formule empirique (notation de Hill): C₃₉H₅₂N₁₂O₆ · xC₂HF₃O₂
• Numéro CAS: 1057258-86-2
• Poids moléculaire : 784.91 (free base basis)
• Numéro MDL: MFCD04112656
• Code UNSPSC : 51111800
• ID de substance PubChem : 329824026
• Nomenclature NACRES : NA.77

Propriétés

• Pureté: ≥98% (reversed phase HPLC)
• Forme: lyophilized solid
• Couleur: white
• Solubilité: H₂O: >10 mg/mL
• Température de stockage: room temp
• Chaîne SMILES: CCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N(C)CC(N)=O
• InChI: 1S/C39H52N12O6/c1-3-10-34(53)47-31(19-26-21-43-23-46-26)37(56)49-30(17-24-11-5-4-6-12-24)36(55)48-29(15-9-16-44-39(41)42)35(54)50-32(38(57)51(2)22-33(40)52)18-25-20-45-28-14-8-7-13-27(25)28/h4-8,11-14,20-21,23,29-32,45H,3,9-10,15-19,22H2,1-2H3,(H2,40,52)(H,43,46)(H,47,53)(H,48,55)(H,49,56)(H,50,54)(H4,41,42,44)/t29-,30-,31-,32-/m0/s1
• Clé InChI: NINOPZAAGJJNAR-YDPTYEFTSA-N

Description

Amino Acid Sequence

Butir-His-Phe-Arg-Trp-Sar-NH2

Actions biochimiques/physiologiques

Ro 27-3225 is a selective melanocortin MC4 receptor agonist. EC50 = 1 nM. Ro 27-3225 shows some activity at the MC1 receptor. Ro 27-3225 reverses hemorrhagic shock, reduces multiple organ damage, and improves survival. Ro 27-3225 may have a protective role against multiple organ failure following circulatory shock. Ro 27-3225 also reduces food intake in ob/ob mice.

Caractéristiques et avantages

This compound is featured on the Melanocortin Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)