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Key Documents

Autres documents

R108

Sigma-Aldrich

Ro 41-0960

solid

Synonyme(s) :

2′-Fluoro-3,4-dihydroxy-5-nitrobenzophenone

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About This Item

Formule empirique (notation de Hill):
C13H8FNO5
Numéro CAS:
125628-97-9
Poids moléculaire :
277.20
Numéro MDL:
MFCD00078597
Code UNSPSC :
12352200
ID de substance PubChem :
24278193
Nomenclature NACRES :
NA.77

Forme

solid

Niveau de qualité

100

Conditions de stockage

protect from light

Couleur

yellow

Solubilité

H2O: slightly soluble <0.7 mg/mL
45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 1.0 mg/mL
ethanol: soluble

Température de stockage

2-8°C

Chaîne SMILES 

Oc1cc(cc(c1O)[N+]([O-])=O)C(=O)c2ccccc2F

InChI

1S/C13H8FNO5/c14-9-4-2-1-3-8(9)12(17)7-5-10(15(19)20)13(18)11(16)6-7/h1-6,16,18H

Clé InChI

RQPAUNZYTYHKHA-UHFFFAOYSA-N

Informations sur le gène

human ... COMT(1312)

Application

Ro 41-0960 has been used as an inhibitor of catechol-O-methyl-transferase in synaptosome membrane preparations and 3T3-L1 adipocytes. It has also been used as a catechol-O-methyl-transferase inhibitor to treat corpus striatum samples to test its effect on dopamine metabolism.

Actions biochimiques/physiologiques

Ro 41-0960 is a specific and synthetic inhibitor of the enzyme catechol-O-methyl-transferase (COMT). It binds to the catalytic site and triggers the inhibition of the methylation property of COMT. Ro 41-0960 is effective on uterine leiomyoma lesions and uterine fibroids.

Caractéristiques et avantages

This compound is featured on the Dopamine and Norepinephrine Metabolism page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Attention

Store tightly sealed at 4 °C, protected from exposure to light.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

Fang Lu et al.
The Journal of steroid biochemistry and molecular biology, 105(1-5), 150-158 (2007-06-22)
Formation of estrogen metabolites that react with DNA is thought to be a mechanism of cancer initiation by estrogens. The estrogens estrone (E(1)) and estradiol (E(2)) can form catechol estrogen (CE) metabolites, catechol estrogen quinones [E(1)(E(2))-3,4-Q], which react with DNA
J A Lavigne et al.
Cancer research, 61(20), 7488-7494 (2001-10-19)
Many of the major identified risk factors for breast cancer are associated with exposure to endogenous estrogen. In addition to the effects of estrogen as a growth factor, experimental and epidemiological evidence suggest that catechol metabolites of estrogen also contribute
A Storch et al.
Molecular pharmacology, 57(3), 589-594 (2000-02-29)
Inhibition of catechol-O-methyltransferase (COMT; EC 2.1.1.6) is a new therapeutic strategy in the treatment of Parkinson's disease. However, nothing is known about the effects of COMT inhibition on levodopa (L-dopa)-induced toxicity in dopamine (DA) neurons. Therefore we evaluated the effects
J W Miller et al.
Clinical neuropharmacology, 20(1), 55-66 (1997-02-01)
L-Dopa is the most effective drug known for the treatment of Parkinson's disease. However, the large doses required to treat this neurodegenerative disorder can significantly affect tissue concentrations of sulfur amino acid metabolites due to peripheral and central O-methylation. These
Mathias E Jensen et al.
Neurochemistry international, 138, 104772-104772 (2020-05-29)
A solid body of preclinical evidence shows that glucagon-like peptide-1 receptor (GLP-1R) agonists attenuate the effects of substance use disorder related behaviors. The mechanisms underlying these effects remain elusive. In the present study, we hypothesized that GLP-1R activation modulates dopaminetransporter
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