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Key Documents

P5498

Sigma-Aldrich

Anti-Pro-NGF antibody produced in rabbit

affinity isolated antibody, lyophilized powder

Synonyme(s) :

Anti-Pro-Nerve Growth Factor

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About This Item

Numéro MDL:
MFCD07370460
Code UNSPSC :
51111800
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Niveau de qualité

200

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

lyophilized powder

Espèces réactives

mouse, rat, human

Technique(s)

immunohistochemistry: suitable
western blot: 1:200-1:500

Numéro d'accès UniProt

P08138

Conditions d'expédition

wet ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... NGFR(4804)
mouse ... Ngfr(18053)
rat ... Ngfr(24596)

Spécificité

Does not cross react with pro-BDNF, pro-NT-3, or mature NGF.

Immunogène

peptide corresponding to amino acid residues 84-104 of rat NGF (precursor). The sequence is identical in mouse and 16/21 residues identical in human.

Forme physique

Lyophilized from phosphate buffered saline, pH 7.4, 1% BSA and <0.1% sodium azide

Notes préparatoires

Reconstitute the lyophilized vial with 0.2 ml deionized water.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H312 - H412

Classification des risques

Acute Tox. 4 Dermal - Aquatic Chronic 3

Code de la classe de stockage

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Comparison of nerve growth factor receptor binding models using heterodimeric muteins
Mehta HM et al
Journal of Neuroscience Research, doi: 10-doi: 10 (2012)
M Fahnestock et al.
Molecular and cellular neurosciences, 18(2), 210-220 (2001-08-25)
Nerve growth factor (NGF) is important for regulation, differentiation, and survival of peripheral and central nervous system neurons, including basal forebrain cholinergic neurons (BFCN) which degenerate in Alzheimer's disease (AD). Mature NGF protein is processed from a larger precursor, proNGF.
Death of injured neurons caused by the precursor of nerve growth factor.
Y-A Barde
Proceedings of the National Academy of Sciences of the United States of America, 101(16), 5703-5704 (2004-04-14)
Bai Lu
Neuron, 39(5), 735-738 (2003-09-02)
Neurotrophins are synthesized first as precursors, followed by maturation through proteolytic removal of the "pro" region. Since pro- and mature neurotrophins elicit opposite functional effects by differential interactions with Trks and p75 receptors, extracellular cleavage represents a new way to
Elahe Karimi et al.
Drug design, development and therapy, 13, 2513-2532 (2019-08-24)
Nowadays, the drug delivery system is important in the treatment of diseases. A polymeric nanoparticle modified by oleic acid (NPMO) as a Thymol (Thy) drug release system was synthesized from Thymbra spicata and its neurotrophic and angiogenic effects on rat's
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