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P0099

Sigma-Aldrich

Paliperidone

≥98% (HPLC)

Synonyme(s) :

3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one

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About This Item

Formule empirique (notation de Hill):
C23H27FN4O3
Numéro CAS:
144598-75-4
Poids moléculaire :
426.48
Numéro MDL:
MFCD00871802
Code UNSPSC :
12352200
ID de substance PubChem :
329820012
Nomenclature NACRES :
NA.77

Niveau de qualité

100

Pureté

≥98% (HPLC)

Forme

powder

Couleur

white to brown

Solubilité

DMSO: 2 mg/mL, clear (warmed)

Auteur

Johnson & Johnson

Température de stockage

room temp

Chaîne SMILES 

CC1=C(CCN2CCC(CC2)c3noc4cc(F)ccc34)C(=O)N5CCCC(O)C5=N1

InChI

1S/C23H27FN4O3/c1-14-17(23(30)28-9-2-3-19(29)22(28)25-14)8-12-27-10-6-15(7-11-27)21-18-5-4-16(24)13-20(18)31-26-21/h4-5,13,15,19,29H,2-3,6-12H2,1H3

Clé InChI

PMXMIIMHBWHSKN-UHFFFAOYSA-N

Informations sur le gène

human ... DRD2(1813) , HTR2A(3356)

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Application

Paliperidone has been used as an atypical antipsychotic drug (AAPD) to study its efficacy in preventing psychopathology of mice prenatally immune challenged with lipopolysaccharide (LPS). It has also been used as an atypical antipsychotic drug (AAPD) to explain the modulation of hypothalamic-pituitary-adrenal (HPA) axis in female mice prenatally treated with bacterial endotoxin lipopolysaccharide (LPS).

Actions biochimiques/physiologiques

Paliperidone is an atypical antipsychotic; active metabolite of risperidone.

Caractéristiques et avantages

This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictogrammes

Skull and crossbones
GHS06

Mention d'avertissement

Danger

Mentions de danger

H301

Classification des risques

Acute Tox. 3 Oral

Code de la classe de stockage

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

Mehrul Hasnain et al.
CNS drugs, 28(10), 887-920 (2014-08-30)
We comprehensively reviewed published literature to determine whether it supported the link between corrected QT (QTc) interval prolongation and torsade de pointes (TdP) for the 11 second-generation antipsychotics and seven second-generation antidepressants commonly implicated in these complications. Using PubMed and
Umesh Kumar et al.
European journal of pharmacology, 747, 181-189 (2014-09-23)
Studies on animal models provide enough evidences that old age appearance of psychosis on exposures to various insults during critical period of brain development could be prevented by antipsychotic drug treatment. Presently, gestational intervention of the atypical antipsychotic paliperidone (PAL)
Eliyahu Dremencov et al.
Psychopharmacology, 194(1), 63-72 (2007-05-29)
Paliperidone (9-OH-risperidone) is the main metabolite of the atypical antipsychotic risperidone. While both drugs are potent dopamine (D)2 antagonists, they have quantitative differential affinities for serotonin (5-HT) and norepinephrine (NE) receptor binding sites. The present study aimed to determine if
Richard Newton et al.
Current medical research and opinion, 28(4), 559-567 (2012-02-11)
Paliperidone palmitate is an atypical long-acting injectable (LAI) antipsychotic that has been approved for use in the US, EU, Australia and numerous other countries for acute and maintenance therapy of schizophrenia. LAI antipsychotics are often viewed as a 'last-resort' treatment
Saeko Ikai et al.
The Journal of clinical psychiatry, 73(8), 1147-1152 (2012-09-13)
While 65%-80% occupancy of dopamine D2 receptors with antipsychotics has been proposed to achieve optimal therapeutic response during acute treatment of schizophrenia, it remains unclear as to whether it is also necessary to maintain D2 receptor occupancy within this "safe"
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