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N216

Sigma-Aldrich

Monoclonal Anti-Na+/Ca2+ Exchanger antibody produced in mouse

clone C2C12

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About This Item

Numéro MDL:
MFCD01865491
Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

mouse

Niveau de qualité

200

Conjugué

unconjugated

Type de produit anticorps

primary antibodies

Clone

C2C12, monoclonal

Forme

liquid

Poids mol.

antigen 120 kDa (mature exchanger)
antigen 160 kDa (non-reduced)
antigen 70 kDa (proteolytic fragment)

Espèces réactives

human, rat, canine, rabbit, guinea pig

Technique(s)

immunohistochemistry (frozen sections): 1:200
immunoprecipitation (IP): suitable
western blot: 1:1,000

Isotype

IgM

Numéro d'accès UniProt

P32418

Conditions d'expédition

dry ice

Température de stockage

−20°C

Informations sur le gène

human ... SLC8A1(6546)

Description générale

Na+/Ca2+ exchanger is also known as solute carrier family 8 member A1 (SLC8A1) and is present in the plasma membrane. It is predicted to have nine transmembrane segments and the gene encoding SLC8A1 has three promoters.

Spécificité

The antibody reacts specifically with Na+/Ca2+ exchanger in kidney and cardiac tissues. By immunohistology, staining of the plasma membrane and intense staining of the cardiac T-tubular membrane is observed. The antibody is not recommended for immunoblotting of rat tissues.

Immunogène

dog cardiac Na+/Ca2+ exchanger. The epitope is in the region of amino acids 371-525, which is on the intracellular side of the plasma membrane.

Actions biochimiques/physiologiques

Na+/Ca2+ exchanger (SLC8A1, solute carrier family 8 member A1) is involved in Ca2+ homeostasis. Depending on physiological conditions prevailing in the cell, it can either pump out Na+ or Ca2+.

Forme physique

Solution in phosphate buffered saline, 1 mg/ml BSA containing 0.05% sodium azide.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

nwg

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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Ping-Chun Li et al.
PloS one, 9(2), e85909-e85909 (2014-02-06)
Levosimendan, a known calcium sensitizer with positive inotropic and vasodilating properties, might also be cardioprotective during ischemia-reperfusion (I/R) insult. Its effects on calcium homeostasis and apoptosis in I/R injury remain unclear. Na(+)/Ca(2+) exchanger (NCX) is a critical mediator of calcium
Kathleen O'Connell et al.
Experimental gerontology, 43(10), 958-961 (2008-09-03)
In skeletal muscle, Ca(2+)-cycling through the sarcoplasm regulates the excitation-contraction-relaxation cycle. Since uncoupling between sarcolemmal excitation and fibre contraction may play a key role in the functional decline of aged muscle, this study has evaluated the expression levels of key
J S Frank et al.
The Journal of cell biology, 117(2), 337-345 (1992-04-01)
The present study reports on the location of the Na(+)-Ca2+ exchanger in cardiac sarcolemma with immunofluorescence and immunoelectron microscopy. Both polyclonal and monoclonal antibodies to the Na(+)-Ca2+ exchanger were used. The mAb was produced from a hybridoma cell line generated
Jia Chang et al.
The Journal of biological chemistry, 282(42), 30938-30948 (2007-08-28)
Mesenchymal stem cells (MSCs) are multipotent cells that can be differentiated into osteoblasts and provide an excellent cell source for bone regeneration and repair. Recently, the canonical Wnt/beta-catenin signaling pathway has been found to play a critical role in skeletal
Julian Vallejo et al.
PloS one, 11(3), e0150066-e0150066 (2016-03-10)
There is growing evidence that severe decline of skeletal muscle mass and function with age may be mitigated by exercise and dietary supplementation with protein and amino acid ingredient technologies. The purposes of this study were to examine the effects
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