N1790

Naftifine hydrochloride

• Synonyme(s) : Naftifine HCL
• Formule empirique (notation de Hill): C₂₁H₂₁N · HCl
• Numéro CAS: 65473-14-5
• Poids moléculaire : 323.86
• Numéro MDL: MFCD00059047
• Code UNSPSC : 51102829
• ID de substance PubChem : 329818590
• Nomenclature NACRES : NA.76

Propriétés

• Pureté: ≥99%
• Forme: powder
• Solubilité: ethanol: soluble 50 mg/mL
• Spectre d'activité de l'antibiotique: Gram-negative bacteria; Gram-positive bacteria; fungi; yeast
• Mode d’action: cell wall synthesis | interferes; enzyme | inhibits
• Température de stockage: 2-8°C
• Chaîne SMILES: Cl.CN(C\C=C\c1ccccc1)Cc2cccc3ccccc23
• InChI: 1S/C21H21N.ClH/c1-22(16-8-11-18-9-3-2-4-10-18)17-20-14-7-13-19-12-5-6-15-21(19)20;/h2-15H,16-17H2,1H3;1H/b11-8+;
• Clé InChI: OLUNPKFOFGZHRT-YGCVIUNWSA-N

Description

Application

Naftifine is a synthetic, broad spectrum, antifungal agent and allylamine derivative. It is used topically to treat superficial dermatomycoses such as tinea pedis, tinea cruris, and tinea corporis.

Actions biochimiques/physiologiques

Naftifine is an allylamine compound that has antifungal and antimycotic activities. Naftifine inhibits fungal squalene epoxidase and prevents ergosterol biosynthesis. Naftifine also has antibiotic activity against Gram-positive and Gram-negative bacteria. It has demonstrated anti-inflammatory properties such as a reduction in superoxide production and a reduction in polymorphonuclear leukocyte chemotaxis/endothelial adhesion. Naftifine appears to interfere with sterol biosynthesis by inhibiting the squalene 2,3-epoxidase. This inhibition results in decreased amounts of ergosterol and an accumulation of squalene in the cells.

Allylamine compound that has antifungal and antimycotic activities. Naftifine inhibits fungal squalene epoxidase and prevents ergosterol biosynthesis. Naftifine also has antibiotic activity against Gram-positive and Gram-negative bacteria and has demonstrated anti-inflammatory properties.

Autres remarques

Keep container tightly closed in a dry and well-ventilated place.Light sensitive.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): nwg
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable