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M6546

Sigma-Aldrich

(±)-2-(p-Methoxyphenoxy)propionic acid

solid, ≥98%

Synonyme(s) :

PMP

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About This Item

Formule empirique (notation de Hill):
C10H12O4
Numéro CAS:
13794-15-5
Poids moléculaire :
196.20
Numéro MDL:
MFCD01310545
Code UNSPSC :
12352202
ID de substance PubChem :
24897095
Nomenclature NACRES :
NA.77

product name

(±)-2-(p-Methoxyphenoxy)propionic acid, ≥98%

Source biologique

synthetic (organic)

Niveau de qualité

200

Pureté

≥98%

Forme

solid

Chaîne SMILES 

COc1ccc(OC(C)C(O)=O)cc1

InChI

1S/C10H12O4/c1-7(10(11)12)14-9-5-3-8(13-2)4-6-9/h3-7H,1-2H3,(H,11,12)

Clé InChI

MIEKOFWWHVOKQX-UHFFFAOYSA-N

Application

(±)-2-(p-Methoxyphenoxy)propionic acid may be used as a sweet taste receptor antagonist to study its effect on allulose-induced glucagon-like peptide 1 (GLP-1) secretion rats. It may also be used to study the response of the secretin tumor cell line (STC-1) to sweetener in the presence and absence of (±)-2-(p-methoxyphenoxy)propionic acid or lactisole.

Actions biochimiques/physiologiques

As a taste modulator, the sodium salt inhibits the perception of sweetness in humans, but not in rats.

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H315,H319,H335

Classification des risques

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Organes cibles

Respiratory system

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

dust mask type N95 (US), Eyeshields, Gloves

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David E Lanfear et al.
JACC. Heart failure, 5(11), 823-832 (2017-11-04)
This study sought to derive and validate plasma metabolite associations with survival in heart failure (HF) patients. Profiling of plasma metabolites to predict the course of HF appears promising, but validation and incremental value of these profiles are less established. Patients
Miguel Concha et al.
Journal of biomedical materials research. Part B, Applied biomaterials, 106(6), 2464-2471 (2018-02-10)
In this study, highly neutralized, highly porous, and ultralight polymeric aerogels prepared from aqueous colloidal suspensions of chitosan (CS) and chondroitin sulfate (ChS) nanocomplexes, formulated as quasi-equimolar amounts of both, are described. These aerogels were designed as healing agents under
Kelly S Barth et al.
The Journal of continuing education in the health professions, 37(2), 98-105 (2017-06-01)
South Carolina (SC) ranks 10th in opioid prescriptions per capita-33% higher than the national average. SC is also home to a large military and veteran population, and prescription opioid use for chronic pain is alarmingly common among veterans, especially those
A Sclafani et al.
Physiology & behavior, 61(1), 25-29 (1997-01-01)
Cypha, propionic acid, 2-(4-methoxyphenol) salt, is a commercially available sweet taste inhibitor used in food products. The present study examined whether or not Cypha blocked the sweet taste response of rats. This was accomplished by measuring the consummatory response of
Yoko Murphy et al.
Pain physician, 18(4), E605-E614 (2015-07-29)
Canada has featured the second-highest levels of prescription opioid (PO) use globally behind the United States, and reported extensive PO-related harms (e.g., non-medical PO use [NMPOU], PO-related morbidity and mortality). A recent comprehensive review synthesized key data on PO use
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