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L1645

Sigma-Aldrich

Anti-Human Lambda Light Chain (Bound and Free) antibody produced in goat

affinity isolated antibody, buffered aqueous solution

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About This Item

Numéro MDL:
MFCD00162516
Code UNSPSC :
12352203
Nomenclature NACRES :
NA.46

Source biologique

goat

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

secondary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Technique(s)

indirect ELISA: 1:2,500

Conditions d'expédition

dry ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

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Catégories apparentées

Description générale

Immunoglobulins (Ig) are produced by the B cells and play crucial role in host humoral immune response. A typical immunoglobulin consists of two heavy chains and two light chains. The two light chains are either κ or the λ chain. The B cells express one type of light chain during their life time.
Lambda (λ) light chain comprises an amino-terminal variable region and carboxy-terminal constant region. λ chain is biologically critical and constitutes up to 30 to 40% of human immunoglobulin (Ig) molecules. The human λ locus is mapped to the chromosome location 22.

Application

Anti-Human Lambda Light Chain (Bound and Free) antibody has been used in surface plasmon resonance assay.
Anti-Human Lambda Light Chain (bound and free) antibody produced in goat has been used in indirect enzyme linked immuno sorbent assay (ELISA).

Forme physique

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide as preservative

Stockage et stabilité

For continuous use, store at 2-8 °C for up to one month.For extended storage, solution may be frozen inworking aliquots. Repeated freezing and thawing is notrecommended. Storage in "frost-free" freezers is notrecommended.If slight turbidity occurs upon prolonged storage, clarify by centrifugation before use.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

12 - Non Combustible Liquids

Classe de danger pour l'eau (WGK)

nwg

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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An anti-TL1A antibody for the treatment of asthma and inflammatory bowel disease
MAbs, 10(4), 664-677 (2018)
Structural and functional properties of human lambda-light-chain variable-region subgroups.
A Solomon et al.
Clinical and diagnostic laboratory immunology, 2(4), 387-394 (1995-07-01)
Adam W Clarke et al.
mAbs, 10(4), 664-677 (2018-02-14)
TL1A is an attractive therapeutic target for the treatment of mucosal inflammation associated with inflammatory bowel disease (IBD) and asthma. Blockade of the TL1A pathway has been shown to reduce inflammatory responses while leaving baseline immunity intact, and to be
Jerry A Katzmann et al.
Clinical chemistry, 48(9), 1437-1444 (2002-08-27)
The detection of monoclonal free light chains (FLCs) is an important diagnostic aid for a variety of monoclonal gammopathies and is especially important in light-chain diseases, such as light-chain myeloma, primary systemic amyloidosis, and light-chain-deposition disease. These diseases are more

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