K3513

Anti-KIF3A antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

• Synonyme(s) : Anti-FLA10, Anti-KLP-20
• Numéro MDL: MFCD03791823
• Code UNSPSC : 12352203
• Nomenclature NACRES : NA.46

Propriétés

• Source biologique: rabbit
• Conjugué: unconjugated
• Forme d'anticorps: IgG fraction of antiserum
• Type de produit anticorps: primary antibodies
• Clone: polyclonal
• Forme: buffered aqueous solution
• Espèces réactives: rat, mouse, human
• Conditionnement: antibody small pack of 25 μL
• Technique(s): immunohistochemistry: suitable using suitable for IHC on rat brain perfused with 4% paraformaldehyde; microarray: suitable; western blot: 1:2,000 using rat brain homogenate and whole cell extract of rat pheochromocytoma PC12 cell line.
• Numéro d'accès UniProt: Q9Y496
• Conditions d'expédition: dry ice
• Température de stockage: −20°C
• Modification post-traductionnelle de la cible: unmodified
• Informations sur le gène: human ... KIF3A(11127) ; mouse ... Kif3a(16568) ; rat ... Kif3a(84392)

Description

Description générale

KIF3A/B is abundantly expressed in neuronal tissue and ubiquitously expressed in other tissues in lower amounts.

The gene KIF3A (kinesin family member 3A) is mapped to human chromosome 5q31.1. The gene encodes a subunit of heterotrimeric kinesin-2, which is a canonical plus-oriented anterograde IFT (intraflagellar transport) motor.

Immunogène

synthetic peptide corresponding to the C-terminus of mouse KIF3A (amino acids 682-701) conjugated to KLH.

Application

Anti-KIF3A antibody produced in rabbit has been used in immunohistochemistry and immunofluorescence.

Anti-KIF3A antibody produced in rabbit has been used in:

• immunoblotting
• immunohistochemical detection of kinesin family member 3A (KIF3A)

Actions biochimiques/physiologiques

The gene KIF3A (kinesin family member 3A) encodes a motor subunit of kinesin-2, a protein that functions in the formation and mechanism of cilia. The chromosomal region to which the gene is mapped is linked to immune diseases, such as asthma.

The kinesin superfamily (KIFs) of proteins consists of a class of microtubule-dependent motors that plays a major role in many cellular and developmental functions, including organelle transport, mitosis, meiosis, and possibly long-range signaling in neurons. KIF3 plays a crucial role during development. KIF3A-/- and KIF3B-/- mice do not survive beyond mid-gestation. Embryos lacking KIF3A and KIF3B display randomization of left-right asymmetry and numerous morphological abnormalities. The KIF3A/B heterodimer exhibits a plus end-directed microtubule sliding activity.

Forme physique

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable