I8534

Anti-Interleukin-1α antibody produced in goat

affinity isolated antibody, lyophilized powder

• Synonyme(s) : Anti-IL-1α
• Numéro MDL: MFCD00165461
• Code UNSPSC : 51111800
• Nomenclature NACRES : NA.41

Propriétés

• Source biologique: goat
• Niveau de qualité: 100
• Conjugué: unconjugated
• Forme d'anticorps: affinity isolated antibody
• Type de produit anticorps: primary antibodies
• Clone: polyclonal
• Forme: lyophilized powder
• Espèces réactives: mouse
• Technique(s): immunohistochemistry: 15 μg/mL; neutralization: suitable; western blot: 0.1-0.2 μg/mL
• Numéro d'accès UniProt: P01582
• Température de stockage: −20°C
• Modification post-traductionnelle de la cible: unmodified
• Informations sur le gène: mouse ... Il1a(16175)

Description

Description générale

Interleukins are proinflammatory cytokines produced on cell injury or trauma. There are two closely related types of interleukins produced by the cell, IL-1α and IL-1β that are produced by the activation of NF-κ B transcription factor in response to bacterial infection or LPS. Both IL-1α and IL-1β exert their cellular effects by signalling through IL-1 receptor type 1. A variety of cells such as macrophages, epithelial cells, fibroblasts, keratinocytes, monocytes and dendritic cells secrete IL-1α. Both IL-1α and IL-1β are important in acquired immunity, inflammation, response to infection and production of matrix metalloproteinases (MMPs). The effects of IL-1α are mediated by activation of NF-κB, JNK and MAPK pathways that activated the genes in response to infection and inflammation. Overproduction of IL-1α has been implicated in inflammatory disorders like rheumatoid arthritis and periodontitis
Anti-interleukin-1α specifically reacts with murine IL-1α.

Immunogène

purified, E. coli-derived recombinant mouse interleukin-1α.

Application

Anti-interleukin 1α antibody may be used for immunoblotting at a working concentration of 0.1-0.2 μg/ml. For immunohistochemistry and immunofluorescence, a working concentration of ~15 μg/ml is recommended. It is also suitable for neutralization reactions.

Forme physique

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.

Informations sur la sécurité

• Code de la classe de stockage: 13 - Non Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)