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Principaux documents

I7389

Interleukin-3 human

Name: Interleukin-3 human
Brand: SIGMA

IL-3, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

Synonyme(s) :

hIL-3, IL-3

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About This Item

Numéro MDL:

MFCD00147276

Code UNSPSC :

12352202

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Sigma-Aldrich

I5879

3-Isobutyl-1-méthylxanthine

Source biologique

human

Niveau de qualité

200

Produit recombinant

expressed in E. coli

Pureté

≥95% (SDS-PAGE)

Forme

lyophilized powder

Puissance

<0.5 ng/mL ED₅₀

Qualité

endotoxin tested

Conditionnement

pkg of 4 μg

Technique(s)

cell culture | mammalian: suitable

Impuretés

<0.1 EU/μg

Numéro d'accès UniProt

P08700

Conditions d'expédition

dry ice

Température de stockage

−20°C

Informations sur le gène

human ... IL3(3562)

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Actions biochimiques/physiologiques

Interleukin-3 (IL-3) is a multifunctional protein, originally called colony forming unit-stimulating activity (CFU-SA), and is produced by activated T lymphocytes. IL-3 supports the formation of multilineage colonies in the early development of multipotent hematopoietic progenitor cells. IL-3 has been shown to induce colony formation of macrophages, neutrophils, mast cells, and megakaryocytes from agar-suspended bone marrow cells. IL-3 also interacts with IL-2 to stimulate growth of T lymphocytes and to induce IgG secretion from activated B cells. Other synonyms for IL-3 include pan-specific hemopoietin, multicolony stimulating factor, mast cell growth factor, burst promoting activity, histamine-producing cell stimulating factor, P cell stimulating factor, and WEHI-3 factor.

Définition de l'unité

One unit is the amount of IL-3 required to induce half-maximal incorportion of ³H thymidine. Activity also is expressed in Reference units (NIBSC reference preparation for IL-3 code 88/87).

Forme physique

Lyophilized from a 0.2 μm filtered solution.

Code de la classe de stockage

12 - Non Combustible Liquids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Certificats d'analyse (COA)

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Basophils exhibit antibacterial activity through extracellular trap formation.

S Yousefi et al.

Allergy, 70(9), 1184-1188 (2015-06-05)

Basophils are primarily associated with immunomodulatory functions in allergic diseases and parasitic infections. Recently, it has been demonstrated that both activated human and mouse basophils can form extracellular DNA traps (BETs) containing mitochondrial DNA and granule proteins. In this report

Low-dose decitabine promotes megakaryocyte maturation and platelet production in healthy controls and immune thrombocytopenia.

Hai Zhou et al.

Thrombosis and haemostasis, 113(5), 1021-1034 (2015-01-09)

Impaired megakaryocyte maturation and insufficient platelet production have been shown to participate in the pathogenesis of immune thrombocytopenia (ITP). Our previous study demonstrated that low expression of tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) in megakaryocytes contributed to impaired platelet production

Genuine Immunomodulation With dSLIM.

Kerstin Kapp et al.

Molecular therapy. Nucleic acids, 3, e170-e170 (2014-06-25)

Toll-like receptors are sensing modulators of the innate immune system. One member of this protein family, Toll-like receptor (TLR)-9, is increasingly being investigated as therapeutic target for infectious diseases and cancer. Double-Stem Loop ImmunoModulator (dSLIM) is a new TLR-9 agonist

Blockade of type I interferon (IFN) production by retroviral replicating vectors and reduced tumor cell responses to IFN likely contribute to tumor selectivity.

Amy H Lin et al.

Journal of virology, 88(17), 10066-10077 (2014-06-27)

We developed a Moloney mouse leukemia virus (MLV)-based retroviral replicating vector (RRV), Toca 511, which has displayed tumor specificity in resected brain tumor material and blood in clinical trials. Here, we investigated the interaction between Toca 511 and human host

Breast Cancer Cell-Derived GM-CSF Licenses Regulatory Th2 Induction by Plasmacytoid Predendritic Cells in Aggressive Disease Subtypes.

Cristina Ghirelli et al.

Cancer research, 75(14), 2775-2787 (2015-05-16)

Reciprocal interactions between tumor cells and their microenvironment vitally impact tumor progression. In this study, we show that GM-CSF produced by primary breast tumor cells induced the activation of plasmacytoid predendritic cells (pDC), a cell type critical to anti-viral immunity.

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