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I5528

Sigma-Aldrich

Interferon-Inducible T Cell α Chemoattractant human

≥97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

Synonyme(s) :

β-R1, H174, I-TAC, SCYB9B

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About This Item

Numéro MDL:
MFCD01867054
Code UNSPSC :
51111800
Nomenclature NACRES :
NA.32

Source biologique

human

Niveau de qualité

200

Produit recombinant

expressed in E. coli

Pureté

≥97% (SDS-PAGE)

Forme

lyophilized powder

Puissance

10-20 ng/mL ED50

Poids mol.

8.3 kDa

Conditionnement

pkg of 25 μg

Technique(s)

cell culture | mammalian: suitable

Impuretés

<0.1ng/mg

Numéro d'accès UniProt

O14625

Température de stockage

−20°C

Informations sur le gène

human ... CXCL11(6373)

Actions biochimiques/physiologiques

I-TAC (Interferon-inducible T-cell α chemoattractant) is a chemokine which participates in recruitment of inflammatory cell. It binds to receptor CXCR3 (C-X-C motif chemokine receptor 3). I-TAC is associated with the severity of dengue.

Forme physique

Lyophilized in 30% acetonitrile and 0.1% trifluoroacetic acid containing 1.25 mg of bovine serum albumin.

Remarque sur l'analyse

The biological activity is measured by its ability to induce chemotaxis in IL-2 cultured human lymphocytes.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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B P Hoh et al.
Human immunology, 76(6), 421-426 (2015-04-11)
Dengue causes significantly more human disease than any other arboviruses. It causes a spectrum of illness, ranging from mild self-limited fever, to severe and fatal dengue hemorrhagic fever, as evidenced by vascular leakage and multifactorial hemostatic abnormalities. There is no
D P Widney et al.
Journal of immunology (Baltimore, Md. : 1950), 164(12), 6322-6331 (2000-06-08)
A new murine chemokine was identified in a search for glucocorticoid-attenuated response genes induced in the lung during endotoxemia. The first 73 residues of the predicted mature peptide are 71% identical and 93% similar to human CXCL11/IFN-inducible T cell alpha
M R Rani et al.
The Journal of biological chemistry, 271(37), 22878-22884 (1996-09-13)
We report preliminary characterization of a gene designated beta-R1, which is selectively expressed in response to interferon beta (IFN-beta) compared with IFN-alpha. In human astrocytoma cells, beta-R1 was induced to an equivalent extent by 10 IU/mL IFN-beta or 2500 IU/mL
Y Luo et al.
Journal of neurovirology, 4(6), 575-585 (1999-03-05)
H174 is a new member of the CXC-chemokine family. A cDNA probe containing the entire H174 coding region recognized a predominant inducible transcript of approximately 1.5 kb expressed in interferon (IFN) activated astrocytoma and monocytic cell lines. H174 message can
R Krishnan Kutty et al.
Cytokine, 74(2), 335-338 (2015-04-22)
Dysfunction of the retinal pigment epithelium (RPE) resulting from chronic inflammation is implicated in the pathogenesis of age-related macular degeneration (AMD). RPE cells adjacent to drusen deposits in the AMD eye are known to contain CXCL11, a chemokine involved in
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