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Key Documents

I3661

Sigma-Aldrich

Insulin-FITC labeled human

recombinant, expressed in yeast, lyophilized powder

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About This Item

Numéro CE :
Code UNSPSC :
12352204
Nomenclature NACRES :
NA.83

Produit recombinant

expressed in yeast

Niveau de qualité

Forme

lyophilized powder
solid

Composition

Insulin, ≥75% biuret

Ampleur du marquage

≥1 mol FITC per mol insulin

Conditions d'expédition

dry ice
dry ice

Température de stockage

−20°C
−20°C

Description générale

Insulin is a polypeptide hormone mainly secreted from pancreas when glucose level changes in the plasma. It is an anabolic hormone and enhances the generation of storage substances, for instance glycogen, fat and protein. It also induces glucose uptake by peripheral tissues, thereby controlling glucose levels in the plasma. Its main sites of action are liver, adipose tissue and muscle.

Application

Insulin-FITC labeled human has been used in primary endothelial cells from human adipose tissue microvasculature (HAMEC) to study insulin transcytosis.

Forme physique

Lyophilized powder containing sodium phosphate buffer salts

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

nwg

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable


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Espinal J
Understanding Insulin Action: Principles and Molecular Mechanisms (1989)
Aaron L Glieberman et al.
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Pancreatic β cell function is compromised in diabetes and is typically assessed by measuring insulin secretion during glucose stimulation. Traditionally, measurement of glucose-stimulated insulin secretion involves manual liquid handling, heterogeneous stimulus delivery, and enzyme-linked immunosorbent assays that require large numbers
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American journal of physiology. Endocrinology and metabolism, 309(1), E35-E44 (2015-05-07)
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