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I2393

Sigma-Aldrich

Interleukin-1β from rat

IL-1β, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

Synonyme(s) :

IL-1β, Interleukin-1β from rat, Lymphocyte activating factor

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About This Item

Numéro MDL:
MFCD01094098
Code UNSPSC :
12352202
Nomenclature NACRES :
NA.77

Source biologique

rat

Niveau de qualité

100

Produit recombinant

expressed in E. coli

Pureté

≥98% (SDS-PAGE and HPLC)

Forme

lyophilized powder

Puissance

0.01-0.1 ng/mL ED50/EC50

Poids mol.

17.3 kDa

Conditionnement

pkg of 10 and 50 μg

Technique(s)

cell culture | mammalian: suitable

Impuretés

<0.1 EU/μg

Numéro d'accès UniProt

Q63264

Température de stockage

−20°C

Informations sur le gène

rat ... Il1b(24494)

Catégories apparentées

Description générale

Interleukin-1 (IL-1), originally known as Lymphocyte Activating Factor (LAF), activates T cells and lymphocytes, which then proliferate and secrete interleukin-2.1 IL-1 is primarily released from stimulated macrophages and monocytes, but is also released from several other cell types,2 and is thought to play a key role in inflammatory and immune responses.3 Other synonyms for IL-1 include: Endogenous Pyrogen (EP), Mitogenic Protein (MP), Helper Peak-1 (HP-1), T Cell Replacing Factor III (TRF III or TRFH), B cell Activating Factor (BAF) and B Cell Differentiation Factor (BDF).4 The two closely related agents, Interleukin-1α (IL-1α) and Interleukin-1β (IL-1β) bind to the same cell surface receptor, elicit nearly identical biological responses and yet share 25% homology in their amino acid sequence. Recombinant rat IL-1β is a 17.3 kDa protein containing 153 amino acid residues.

Forme physique

Lyophilized from a 0.2 μm filtered buffered solution.

Remarque sur l'analyse

The biological activity is measured in a cell proliferation assay using murine D10S cells.

Formule chimique

1. Gery, I., et al., J. Exp. Med., 136, 128 (1972).
2. Oppenheim, J. J., et al., Immunol. Today, 7, 45 (1986).
3. Durum, S. K., et al., Annu. Rev. Immunol., 3, 263 (1985).
4. Aarden, L., et al., J. Immunol., 123, 2928 (1979).
5. Symons, J., et al., Lymphokines and Interferons, A Practical Approach, Clemens, M., et al., (eds.), IRL Press, Oxford (1987).

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

Wei Zhou et al.
Journal of neurophysiology, 117(6), 2282-2291 (2017-03-17)
Excessive inflammation including IL-1β-initiated signaling is among the earlies reactions that can cause neuronal damage following spinal cord injury (SCI). It has been suggested that microRNAs may participate in stem cell repair to facilitate functional recovery following SCI. In this

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Interleukin Family (IL)

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