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Merck
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I2386

Sigma-Aldrich

Anti-Human IgM (μ-chain specific) antibody produced in goat

affinity isolated antibody, buffered aqueous solution

Synonyme(s) :

Anti-IgM produced in Goat, Goat Anti-Human IgM, IgM Detection Antibody

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About This Item

Numéro MDL:
MFCD00162459
Code UNSPSC :
12352203
Nomenclature NACRES :
NA.46

Source biologique

goat

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

secondary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Technique(s)

indirect ELISA: 1:20,000-1:40,000

Conditions d'expédition

dry ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

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Description générale

IgM antibodies are present as pentamers in the serum and are produced in response to antigens.

Application

Anti-Human IgM (μ-chain specific) antibody produced in goat has been used in enzyme linked immunosorbent assay (ELISA).

Actions biochimiques/physiologiques

Immunoglobulin M (IgM) antibodies are the primary ones to be produced in response to antigen. They bind with low affinity but exhibit a broad specificity to a variety of antigens. IgM constitutes 15% of adult immunoglobulins. IgM is important for fetal and neonatal host defenses for several reasons. IgM molecule efficiently activates classical pathway of complement. Its pentameric structure helps in accomodating multivalent ligand binding. IgM has a prominent role in clearance of invading microorganisms from serum.

Forme physique

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Certificats d'analyse (COA)

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Juha Ollila et al.
Molecular immunology, 44(14), 3537-3551 (2007-05-09)
B-cell development into antibody producing cells is a complex process that relies on the tightly controlled production of hundreds of genes and proteins. A B-cell is activated through the B-cell receptor (BCR) and this activation is modified by different co-stimulatory
Avery's Diseases of the Newborn E-Book, 460-460 (2011)
Anti-protein immunoglobulin M responses to pneumococcus are not associated with aging
German EL, et al.
Pneumonia (Nathan Qld.), 10(1), 5-5 (2018)
X Guo et al.
Oncogene, 36(29), 4224-4232 (2017-04-04)
Diffuse large B-cell lymphoma (DLBCL) has been categorized into two molecular subtypes that have prognostic significance, namely germinal center B-cell like (GCB) and activated B-cell like (ABC). Although ABC-DLBCL has been associated with NF-κB activation, the relationships between activation of
J Ollila et al.
Genes and immunity, 4(5), 343-350 (2003-07-09)
The development of adaptive immunity and responses to foreign molecules and organisms relies on the highly regulated production of hundreds of proteins. B-cell maturation, from committed progenitors to terminally differentiated plasma cells, is a multistep process that requires the ordered
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