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Key Documents

I0531

Sigma-Aldrich

Interleukin-18 from rat

>97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder

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About This Item

Numéro MDL:
Code UNSPSC :
12352202
Nomenclature NACRES :
NA.32

Source biologique

rat

Niveau de qualité

Produit recombinant

expressed in E. coli

Pureté

>97% (SDS-PAGE)

Forme

lyophilized powder

Puissance

10-60 ng/mL ED50

Poids mol.

predicted mol wt ~18.4 kDa

Conditionnement

pkg of 25 μg

Impuretés

endotoxin, tested

Numéro d'accès UniProt

Conditions d'expédition

dry ice

Température de stockage

−20°C

Informations sur le gène

rat ... Il18(29197)

Actions biochimiques/physiologiques

Interleukin 18, also known as interferon-γ-inducing factor (IGIF) and IL-1γ, is a proinflammatory cytokine. It is an inducer of IFN-γ and Th1 (T cell helper type 1) responses (cell differentiation, cell-mediated cytotoxicity and inflammation). IL-18 induces the migration of microvascular endothelial cells.

Forme physique

Lyophilized from 20 mM Tris , 500 mM NaCl, 0.5 mM EDTA, 1 mM TCEP, 0.05% (w/v) PEG8000 pH 8.0 with 5% Trehalose,and 50 μg BSA per μg IL-18

Remarque sur l'analyse

The biological activity is measured by its ability to induce mouse IFN-γ production by activated mouse T cells.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable


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Weiyi He et al.
Cytokine, 68(1), 32-39 (2014-05-03)
CD4(+) T cell polarization plays a critical role in the pathogenesis of allergy. How to modulate the skewed CD4(+) T cell polarization is less clear. The specific immunotherapy (SIT) is the only specific remedy for the treatment of allergic diseases;
M Dagenais et al.
Mucosal immunology, 9(1), 146-158 (2015-06-04)
Cellular inhibitors of apoptosis proteins (cIAPs) are critical arbiters of cell death and key mediators of inflammation and innate immunity. cIAP2 is frequently overexpressed in colorectal cancer and in regenerating crypts of ulcerative colitis patients. However, its corresponding functions in
Camille Guillerey et al.
Oncoimmunology, 4(9), e1027468-e1027468 (2015-09-26)
The Toll-like receptor 3 (TLR3) agonist poly(I:C) is a promising adjuvant for cancer vaccines due to its induction of potent antitumor responses occurring primarily through the activation of dendritic cells (DCs) and natural killer (NK) cells. However, little is known
Jochem W van der Veen et al.
Regulatory toxicology and pharmacology : RTP, 69(3), 371-379 (2014-05-13)
The currently available animal-free methods for the detection of skin sensitizing potential of chemicals seem promising. However, no single method is able to comprehensively represent the complexity of the processes involved in skin sensitization. To ensure a mechanistic basis and
Anders Elm Pedersen et al.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, 123(7), 547-555 (2015-04-25)
TL1A is a TNF-like cytokine which has been shown to co-stimulate TH1 and TH17 responses during chronic inflammation. The expression of this novel cytokine has been investigated in inflammatory disorders like rheumatoid arthritis and inflammatory bowel disease, but little is

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