HPA010546
Anti-CYSLTR1 antibody produced in rabbit
Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
Synonyme(s) :
Anti-CysLTR1 antibody produced in rabbit, Anti-Cysteinyl leukotriene D4 receptor antibody produced in rabbit, Anti-Cysteinyl leukotriene receptor 1 antibody produced in rabbit, Anti-HG55 antibody produced in rabbit, Anti-HMTMF81 antibody produced in rabbit, Anti-LTD4 receptor antibody produced in rabbit
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About This Item
Produits recommandés
Source biologique
rabbit
Conjugué
unconjugated
Forme d'anticorps
affinity isolated antibody
Type de produit anticorps
primary antibodies
Clone
polyclonal
Gamme de produits
Prestige Antibodies® Powered by Atlas Antibodies
Forme
buffered aqueous glycerol solution
Espèces réactives
human
Technique(s)
immunoblotting: 0.04-0.4 μg/mL
immunohistochemistry: 1:200-1:500
Séquence immunogène
RLSTFRKHSLSSVTYVPRKKASLPE
Numéro d'accès UniProt
Conditions d'expédition
wet ice
Température de stockage
−20°C
Modification post-traductionnelle de la cible
unmodified
Informations sur le gène
human ... CYSLTR1(10800)
Description générale
CYSLTR1 (cysteinyl leukotriene receptor 1) is a GPCR (G-protein couple receptor), which functions as a receptor for CysLTs, such as, LTC4 (leukotriene C4), LTD4, and LTE4. This receptor is expressed by epithelial cells, and translocates to nucleus from cell membrane in a ligand-dependent manner. It also resides in the cytoplasm.
Immunogène
Cysteinyl leukotriene receptor 1 recombinant protein epitope signature tag (PrEST)
Application
All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry.
The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies® protocols and other useful information.
The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies® protocols and other useful information.
Actions biochimiques/physiologiques
CYSLTR1 (cysteinyl leukotriene receptor 1) participates in inflammatory processes, and its antagonists are used in the treatment of bronchial asthma. It also regulates vascular permeability and is involved in ischemic brain injury. It elicits elevation in blood-brain barrier permeability, and thus, brain edema and ischemia. In house dust mite-allergic individuals, the expression of CYSLTR1 by T-cells is increased in a IL-4-dependent manner, when sensitized by Dermatophagoides pteronyssinus allergen. Its expression is also linked with bronchial inflammation in COPD (chronic obstructive pulmonary disorder) patients with severe exacerbations. This receptor might be involved in the pathogenesis of adenoid hypertrophy, as it is highly expressed in the adenoid tissues of children with AH. Studies in Chinese children show that the expression level of this receptor in upper-airway tonsillar tissues determines the severity of sleep-disordered breathing (SDB).
Caractéristiques et avantages
Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.
Every Prestige Antibody is tested in the following ways:
Every Prestige Antibody is tested in the following ways:
- IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
- Protein array of 364 human recombinant protein fragments.
Liaison
Corresponding Antigen APREST74425
Forme physique
Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide
Informations légales
Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany
Clause de non-responsabilité
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Code de la classe de stockage
10 - Combustible liquids
Classe de danger pour l'eau (WGK)
WGK 1
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Équipement de protection individuelle
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Certificats d'analyse (COA)
Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".
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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.
Maryse Thivierge et al.
Journal of immunology research, 2015, 384780-384780 (2015-04-29)
In order to determine the potential for allergen to modulate T cell expression of the CysLT1 receptor and responsiveness to leukotrienes, peripheral blood mononuclear cells from house dust mite-allergic or nonallergic individuals were incubated with D. pteronyssinus allergen (Der p).
San-hua Fang et al.
Acta pharmacologica Sinica, 33(12), 1511-1517 (2012-10-23)
Cysteinyl leukotriene receptor 1 (CysLT(1) receptor) is located in epithelial cells, and translocates from the plasma membrane to the nucleus in a ligand-dependent manner. Here, we investigated whether CysLT(1) receptors translocated to the nucleus in endothelial cells after ischemic insult
Mei-Hua Zhu et al.
Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics, 17(2), 159-163 (2015-03-12)
To examine the expression of cysteinyl leukotriene receptor-1 (CysLTR-1) and cysteinyl leukotriene receptor-2 (CysLTR-2) in the adenoid tissues from children with adenoid hypertrophy (AH) and to explore the role of leukotrienes in the pathogenesis of AH. Sixty children with AH
Yuelin Shen et al.
International immunopharmacology, 13(4), 371-376 (2012-05-29)
Evidence suggests that increased leukotriene level and receptor protein expression emerged in the adenotonsillar tissue of children with sleep-disordered breathing (SDB). Nevertheless, few studies have investigated the contribution of disease severity in the cysteinyl leukotriene (CysLT) production and cysteinyl leukotriene
Rakesh Kumar Singh et al.
The Journal of asthma : official journal of the Association for the Care of Asthma, 50(9), 922-931 (2013-07-19)
Leukotrienes (LTs) including cysteinyl leukotrienes (CysLTs) and LTB4 are the most potent inflammatory lipid mediators and play a central role in the pathophysiology of asthma and other inflammatory diseases. These biological molecules mediate a plethora of contractile and inflammatory responses
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