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Key Documents

H9262

Sigma-Aldrich

(Hydroxypropyl)methyl cellulose

viscosity 80-120 cP, 2 % in H2O(20 °C)(lit.)

Synonyme(s) :

2-Hydroxypropyl methyl cellulose ether

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About This Item

Numéro CAS:
Numéro MDL:
Code UNSPSC :
12352201
Nomenclature NACRES :
NA.56

Forme

powder

Niveau de qualité

Poids mol.

~26 kDa

Couleur

beige

Viscosité

80-120 cP, 2 % in H2O(20 °C)(lit.)

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Application

(Hydroxypropyl)methyl cellulose acts as a thickener for aqueous and non-aqueous systems, is a water retention aid and steric stabilizer, and clear films with grease resistance. (Hydroxypropyl)methyl cellulose has been used to study mucoadhesion in the design of drug delivery systems to prolong intestinal residence time and has also been used to study the enhancement of dissolution rate of poorly water soluble drugs.
Thickener for aqueous and non-aqueous systems, clear films with grease resistance, binders, lubricants, steric stabilizer and water retention aid.

Caractéristiques et avantages

Dissolves in water, undergoes reversible gelation upon heating, non-ionic, does not complex with ionic species and is surface active and enzyme resistant. Solutions are pseudoplastic.

Autres remarques

To gain a comprehensive understanding of our extensive range of Polysaccharides for your research, we encourage you to visit our Carbohydrates Category page.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)


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Deirdre M D'Arcy et al.
AAPS PharmSciTech, 20(2), 47-47 (2019-01-09)
Viscosity, influenced by medium composition, will affect the hydrodynamics of a dissolution system. Dissolution simulation methods are valuable tools to explore mechanistic dissolution effects, with an understanding of limitations of any simulation method essential to its appropriate use. The aims
Lucas Sievens-Figueroa et al.
International journal of pharmaceutics, 423(2), 496-508 (2011-12-20)
The design and feasibility of a simple process of incorporating stable nanoparticles into edible polymer films is demonstrated with the goal of enhancing the dissolution rate of poorly water soluble drugs. Nanosuspensions produced from wet stirred media milling (WSMM) were
A Akbarian et al.
Poultry science, 93(8), 1930-1941 (2014-06-17)
Heat stress in poultry is a serious problem in many countries and has been associated with oxidative stress. Hence, nutritional interventions with antioxidants might be beneficial. Therefore, the effects of dietary Curcuma xanthorrhiza (CX) and Origanum compactum (OC) essential oils
Francis W Hunter et al.
Biochemical pharmacology, 89(2), 224-235 (2014-03-19)
The nitro-chloromethylbenzindoline prodrug SN29428 has been rationally designed to target tumour hypoxia. SN29428 is metabolised to a DNA minor groove alkylator via oxygen-sensitive reductive activation initiated by unknown one-electron reductases. The present study sought to identify reductases capable of activating
Michelle Lay Teng Ang et al.
Infection and immunity, 82(5), 1850-1859 (2014-02-26)
Tuberculosis remains a major worldwide epidemic because of its sole etiological agent, Mycobacterium tuberculosis. Ethionamide (ETH) is one of the major antitubercular drugs used to treat infections with multidrug-resistant M. tuberculosis strains. ETH is a prodrug that requires activation within

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