G5171

Anti-Granulocyte Colony Stimulating Factor antibody produced in goat

IgG fraction of antiserum, lyophilized powder

• Synonyme(s) : Anti-G-CSF
• Numéro MDL: MFCD00211951
• Code UNSPSC : 51111800
• Nomenclature NACRES : NA.41

Propriétés

• Source biologique: goat
• Conjugué: unconjugated
• Forme d'anticorps: IgG fraction of antiserum
• Type de produit anticorps: primary antibodies
• Clone: polyclonal
• Forme: lyophilized powder
• Espèces réactives: human
• Technique(s): neutralization: suitable; western blot: 1-2 μg/mL
• Numéro d'accès UniProt: P09919
• Température de stockage: −20°C
• Modification post-traductionnelle de la cible: unmodified
• Informations sur le gène: human ... CSF3(1440)

Description

Description générale

Mature myeloid cells are derived from bone-marrow derived precursor cells by the activity of three colony stimulating factors, granulocyte/macrophage colony-stimulating factor (GM-CSF), macrophage colony-stimulating factor (M-CSF) and granulocyte colony-stimulating factor (G-CSF). The expression of G-CSF is the result of activation of pathways in response to tumor necrosis factor-α, LPS and toll-like receptor ligands. The pathways that induce the effects of G-CSF are PI3K, ERK1/2 and p38. The generation of neutrophils and induction of the circulation of hematopoietic stem cells from the bone marrow are the main functions of G-CSF. There are additional activities attributed to G-CSF such as neuroprotection, immunomodulation and generation of cardiac cells and dendritic cells. Large quantities of G-CSF are secreted in a variety of myeloid and non-myeloid cancers and rheumatoid arthritis
Monoclonal anti-granulocyte colony stimulating factor recognizes human G-CSF.

Immunogène

purified, recombinant human granulocyte colony stimulating factor, expressed in E. coli.

Application

Anti-granulocyte colony stimulating factor antibody may be used for immunoblotting at a working concentration of 1-2 μg/ml. The antibody is also suitable for neutralization assays.

Forme physique

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.