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Key Documents

F9765

Sigma-Aldrich

Filipin complex

powder, ≥70% (UV)

Synonyme(s) :

Filimarisin

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About This Item

Numéro CAS:
11078-21-0
Numéro MDL:
MFCD00131073
Code UNSPSC :
12352202
Nomenclature NACRES :
NA.77

product name

Filipin complex from Streptomyces filipinensis, ≥70% (UV)

Source biologique

Streptomyces sp. (Streptomyces filipinensis)

Niveau de qualité

200

Pureté

≥70% (UV)

Forme

powder

Solubilité

methanol: 9.80-10.20 mg/mL, clear to hazy, yellow to very deep greenish-yellow

Spectre d'activité de l'antibiotique

fungi

Mode d’action

cell membrane | interferes

Température de stockage

−20°C

InChI

1S/C35H58O11/c1-4-5-11-16-31(42)34-33(44)22-29(40)20-27(38)18-25(36)17-26(37)19-28(39)21-32(43)23(2)14-12-9-7-6-8-10-13-15-30(41)24(3)46-35(34)45/h6-10,12-15,24-34,36-44H,4-5,11,16-22H2,1-3H3/b7-6+,10-8+,12-9+,15-13+,23-14+/t24-,25+,26-,27+,28-,29+,30+,31-,32+,33+,34-/m1/s1

Clé InChI

IMQSIXYSKPIGPD-YQRUMEKGSA-N

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Description générale

Chemical structure: macrolide

Application

Filipin complex from Streptomyces filipinensis has been used as a profluorescence probe to detect the free cholesterol in cell.

Actions biochimiques/physiologiques

Filipin is a polyene macrolide antibiotic and antifungal. The antifungal mechanism of action is unclear but may be due to altering membrane permeability. Filipin binds to model crystalline phase lipid bilayers containing cholesterol, and to liquid phase bilayers with or without cholesterol, in an orientation that forms membrane pores.It both inhibits prion protein (PrP) endocytosis and causes the release of PrP from the plasma membrane.

Autres remarques

Filipin contains 8 isomeric components, with filipin III as the major component.

Produit(s) apparenté(s)

Réf. du produit
Description
Tarif

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H315,H319,H335

Classification des risques

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Organes cibles

Respiratory system

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Deqiang Zhang et al.
The Journal of clinical investigation, 127(7), 2855-2867 (2017-06-20)
Epidemiologic and animal studies implicate overconsumption of fructose in the development of nonalcoholic fatty liver disease, but the molecular mechanisms underlying fructose-induced chronic liver diseases remain largely unknown. Here, we have presented evidence supporting the essential function of the lipogenic
Glenda M Halliday et al.
Brain : a journal of neurology, 128(Pt 11), 2654-2664 (2005-07-08)
The distribution and tempo of neuronal loss in Parkinson's disease correlates poorly with the characteristic and more widely spread intracellular changes associated with the disease process (Lewy bodies and Lewy neurites). To determine early intracellular changes in regions where cell
Yvonne Baumer et al.
EBioMedicine, 59, 102876-102876 (2020-07-11)
Inflammation plays an important role in the development of cardiovascular disease (CVD). Patients with chronic inflammation diseases have high levels of inflammation and early fatal myocardial infarction due to early, unstable coronary plaques. Cholesterol crystals (CC) play a key role
Yan-Ning Rui et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 43(6), 2200-2211 (2017-10-27)
We recently discovered that harmful variants in THSD1 (Thrombospondin type-1 domain-containing protein 1) likely cause intracranial aneurysm and subarachnoid hemorrhage in a subset of both familial and sporadic patients with supporting evidence from two vertebrate models. The current study seeks
Lysosomal membrane stability plays a major role in the cytotoxic activity of the anti-proliferative agent, di-2-pyridylketone 4, 4-dimethyl-3-thiosemicarbazone (Dp44mT)
Gutierrez EM,et al.
Biochimica et Biophysica Acta - Molecular Cell Research, 1863(7), 1665-1681 (2016)
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