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F2177

Sigma-Aldrich

Follistatin 288 from mouse

>95% (SDS-PAGE), recombinant, expressed in baculovirus infected Sf21 cells, lyophilized powder

Synonyme(s) :

FS-288

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About This Item

Numéro MDL:
MFCD03456879
Code UNSPSC :
51111800
Nomenclature NACRES :
NA.32

Source biologique

mouse

Niveau de qualité

100

Produit recombinant

expressed in baculovirus infected Sf21 cells

Pureté

>95% (SDS-PAGE)

Forme

lyophilized powder

Puissance

0.04-0.4 mg per mL

Poids mol.

calculated mol wt ~31 kDa

Conditionnement

pkg of 25 μg

Conditions de stockage

avoid repeated freeze/thaw cycles

Impuretés

endotoxin, tested

Numéro d'accès UniProt

P47931

Température de stockage

−20°C

Informations sur le gène

mouse ... Fst(14313)

Description générale

FST (follistatin) is an activin-binding protein, and exists in two isoforms due to alternate splicing, FS288 and FS315. It is a glycoprotein with a single chain, and acts as an activin antagonist. It has a high level of expression in fetal membranes and placenta.

Actions biochimiques/physiologiques

FST (follistatin) binds to and regulates activins, which in turn are TGF (transforming growth factor)-β superfamily members. The expression level of FST and its binding partner activin A is elevated in inflammatory disorders. The activin A-follistatin system plays an essential role in the modulation of glucose and lipid metabolism, which might have an overall effect on fetal growth. In adipose tissue, it facilitates the adipogenic differentiation of progenitor cells.
High affinity activin-binding protein that can act as an activin antagonist.

Forme physique

Recombinant Mouse Follistatin 288 is supplied as a approximately 25 μg of protein lyophilized from a 0.2 μm filtered solution in 30% acetonitrile and 0.1% TFA containing 1.25 mg of bovine serum albumin.

Remarque sur l'analyse

The biological activity is measured by its ability to neutralize activin-induced erythroid differentiation on K562 cells.

Pictogrammes

Corrosion
GHS05

Mention d'avertissement

Danger

Mentions de danger

H315,H318

Classification des risques

Eye Dam. 1 - Skin Irrit. 2

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Rita Linko et al.
BMC infectious diseases, 14, 253-253 (2014-06-03)
Activin A and its binding protein follistatin (FS) are increased in inflammatory disorders and sepsis. Overexpression of activin A in the lung causes similar histopathological changes as acute respiratory distress syndrome (ARDS). ARDS and severe respiratory failure are complications of
Silvia Näf et al.
PloS one, 9(4), e92175-e92175 (2014-04-26)
The Activin A-Follistatin system has emerged as an important regulator of lipid and glucose metabolism with possible repercussions on fetal growth. To analyze circulating activin A, follistatin and follistatin-like-3 (FSTL3) levels and their relationship with glucose metabolism in pregnant women
S Dasgupta et al.
Journal of postgraduate medicine, 58(3), 190-193 (2012-10-02)
Out of a panel of 37 candidate genes tested for linkage with polycystic ovary syndrome (PCOS), the strongest evidence of linkage was reported in the follistatin (FST) gene region. Subsequently, a couple of studies outside India investigated the FST gene

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