E8031

Esmolol hydrochloride

≥98% (HPLC), solid

• Synonyme(s) : 4-[2-Hydroxy-3-[(1-methylethyl)amino]propoxy]benzenepropanoic acid methyl ester hydrochloride hydrochloride
• Formule empirique (notation de Hill): C₁₆H₂₆NClO₄
• Numéro CAS: 81161-17-3
• Poids moléculaire : 331.83
• Numéro MDL: MFCD00941432
• Code UNSPSC : 12352200
• ID de substance PubChem : 329799075
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Pureté: ≥98% (HPLC)
• Forme: solid
• Conditions de stockage: desiccated
• Pf: 89.0-90.6 °C
• Solubilité: H₂O: 12 mg/mL
• Auteur: Baxter
• Température de stockage: 2-8°C
• Chaîne SMILES: Cl.COC(=O)CCc1ccc(OCC(O)CNC(C)C)cc1
• InChI: 1S/C16H25NO4.ClH/c1-12(2)17-10-14(18)11-21-15-7-4-13(5-8-15)6-9-16(19)20-3;/h4-5,7-8,12,14,17-18H,6,9-11H2,1-3H3;1H
• Clé InChI: GEKNCWBANDDJJL-UHFFFAOYSA-N
• Informations sur le gène: human ... ADRB1(153) , ADRB2(154)

Description

Application

Esmolol hydrochloride (ESM) may be used as a standard in spectrophotometric and electrochemical method for the determination of ESM in biological samples and pharmaceutical formulations.

Actions biochimiques/physiologiques

Esmolol hydrochloride (ESM) is a class II antiarrhythmic drug. It is used to decrease the force and rate of heart contractions during surgery. Overdose of ESM can lead to side effects such as bradycardia, cardiac arrest, hypoventilation, mood disorder, and coma.

Esmolol hydrochloride is a ultrashort-acting β₁ adrenoceptor antagonist (β₁ receptor occupancy = 84.7%).

Caractéristiques et avantages

This compound is featured on the β-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Baxter. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves