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E7909

Sigma-Aldrich

Anti-Exportin 1/Crm1 (C-terminal) antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution

Synonyme(s) :

Anti-XPO1

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Niveau de qualité

200

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Poids mol.

antigen ~125 kDa

Espèces réactives

human

Conditionnement

antibody small pack of 25 μL

Concentration

~1.0 mg/mL

Technique(s)

western blot: 2-4 μg/mL using K562 cell lysates

Numéro d'accès UniProt

O14980

Conditions d'expédition

dry ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... XPO1(7514)
mouse ... Xpo1(103573)
rat ... Xpo1(85252)

Catégories apparentées

Description générale

Exportin 1/Crm1 (also known as XPO1, Exp1, chromosome region maintenance 1 protein homolog) is mapped to human chromosome 2p15.

Application

Anti-Exportin 1/Crm1 (C-terminal) antibody produced in rabbit has been used in immunoblotting.

Actions biochimiques/physiologiques

Exportin 1/Crm1 has been implicated in various steps during mitosis.
Exportin-1 is a protein encoded by the XPO1 gene in humans. It is a novel cell-cycle regulated gene that is essential for the nuclear export signal-dependent nuclear export of proteins. XPO1 is highly expressed in mantle cell lymphoma (MCL) cells. It acts as selective inhibitor of nuclear export (SINE) compounds that induce apoptosis in MCL cells. XPO1 is expressed in subpopulation of Gastric cancer (GC) with aggressive behavior and can serve as a prognosis marker for poor outcome. It has helical hairpin HEAT repeats and a C-terminal helical extension (C-extension). The C-extension helps in regulating CRM1′s cargo-binding affinity by modulating the conformation and flexibility of its HEAT repeats.

Forme physique

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

12 - Non Combustible Liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

CRM1-mediated nuclear export: to the pore and beyond
Hutten S, et al.
Trends in Cell Biology, 193-201 (2007)
Toshie Sakuma et al.
Journal of virology, 88(8), 4069-4082 (2014-01-31)
Intron-containing mRNAs are subject to restricted nuclear export in higher eukaryotes. Retroviral replication requires the nucleocytoplasmic transport of both spliced and unspliced RNA transcripts, and RNA export mechanisms of gammaretroviruses are poorly characterized. Here, we report the involvement of the
J Schmidt et al.
Leukemia, 27(12), 2357-2365 (2013-06-12)
RNA interference screening identified XPO1 (exportin 1) among the 55 most vulnerable targets in multiple myeloma (MM). XPO1 encodes CRM1, a nuclear export protein. XPO1 expression increases with MM disease progression. Patients with MM have a higher expression of XPO1
Fang Zhou et al.
Medical oncology (Northwood, London, England), 30(4), 726-726 (2013-09-13)
Gastric cancer (GC) is a highly aggressive malignant tumor. Its high mortality rate prompts the urgent need for novel therapeutic agents. The aim of this study is to detect the expression of CRM1 in GC, which has not been reported
Effects of exportin 1 on nuclear transport and meiotic resumption in porcine full-grown and growing oocytes
Onuma A, et al.
Biology of Reproduction, 98(4), 501-509 (2017)
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