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E0657

Sigma-Aldrich

Monoclonal Anti-phospho-Epidermal Growth Factor Receptor (pTyr1068) antibody produced in mouse

clone 338324, purified immunoglobulin, lyophilized powder

Synonyme(s) :

Monoclonal Anti-EGFR, Monoclonal Anti-ERBB, Monoclonal Anti-HER1, Monoclonal Anti-PIG61

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

mouse

Niveau de qualité

100

Conjugué

unconjugated

Forme d'anticorps

purified immunoglobulin

Type de produit anticorps

primary antibodies

Clone

338324, monoclonal

Forme

lyophilized powder

Espèces réactives

human

Technique(s)

flow cytometry: 5 μg/mL
western blot: 1 μg/mL

Isotype

IgG2a

Numéro d'accès UniProt

P00533

Température de stockage

−20°C

Informations sur le gène

human ... EGFR(1956)

Catégories apparentées

Immunogène

purified, synthetic phosphopeptide corresponding to residues surrounding tyrosine 1068 of human epidermal growth factor receptor.

Actions biochimiques/physiologiques

EGFR is a transmembrane glycoprotein that binds to the EGF family. It is a pivotal regulator of cell proliferation, growth, differentiation and DNA repair after radiation-induced damage. Mutations in the gene encoding EGFR are associated with a number of malignancies including lung cancer and colorectal cancer. Tyr1068 is a minor autophosphorylation site and enables the binding of EGFR to GAB-1 or Grb2.

Forme physique

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Produit(s) apparenté(s)

Réf. du produit
Description
Tarif

E6154

Anti-phospho-Epidermal Growth Factor Receptor (pTyr1068) antibody produced in rabbit, affinity isolated antibody, buffered aqueous glycerol solution

E6279

Anti-phospho-Epidermal Growth Factor Receptor (pTyr1173) antibody produced in rabbit, affinity isolated antibody, buffered aqueous glycerol solution

E1530

Anti-phospho-Epidermal Growth Factor Receptor (pTyr1086) antibody produced in rabbit, affinity isolated antibody, buffered aqueous glycerol solution

E1655

Anti-phospho-Epidermal Growth Factor Receptor [pTyr1148] antibody produced in rabbit, affinity isolated antibody, buffered aqueous glycerol solution

E1780

Anti-phospho-Epidermal Growth Factor Receptor (pTyr992) antibody produced in rabbit, affinity isolated antibody, buffered aqueous glycerol solution

Code de la classe de stockage

13 - Non Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Fen Wang et al.
Journal of experimental & clinical cancer research : CR, 31, 65-65 (2012-08-21)
EGFR mutation is a strong predictive factor of EGFR-TKIs therapy. However, at least 10% of patients with EGFR wild-type are responsive to TKIs, suggesting that other determinants of outcome besides EGFR mutation might exist. We hypothesized that activation of phosphorylated
Jing Bai et al.
Asian Pacific journal of cancer prevention : APJCP, 13(10), 4879-4881 (2012-12-19)
Epidermal growth factor receptor (EGFR) overexpression is associated with resistance to chemotherapy and radiotherapy. The EGFR modulates DNA repair after radiation-induced damage through an association with the catalytic subunit of DNA protein kinase. DNA double-strand breaks (DSBs) are the most
Thu H Truong et al.
Biochemistry, 51(50), 9954-9965 (2012-11-29)
Epidermal growth factor receptor (EGFR) exemplifies the family of receptor tyrosine kinases that mediate numerous cellular processes, including growth, proliferation, and differentiation. Moreover, gene amplification and EGFR mutations have been identified in a number of human malignancies, making this receptor
Ming Qian et al.
Oncology reports, 32(4), 1681-1688 (2014-10-21)
The aim of the present study was to evaluate the potency of epidermal growth factor receptor (EGFR) pathway inhibition achieved by combining cetuximab (CET), an anti-EGFR monoclonal antibody, and celecoxib (CXB), a cyclooxygenase-2 (COX-2) inhibitor, in oral squamous cell carcinoma
Javier Palazuelos et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(36), 11884-11896 (2014-09-05)
Several studies have elucidated the significance of a disintegrin and metalloproteinase proteins (ADAMs) in PNS myelination, but there is no evidence if they also play a role in oligodendrogenesis and CNS myelination. Our study identifies ADAM17, also called tumor necrosis
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