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D8941

Sigma-Aldrich

2,6-Difluoro-4-[2-(phenylsul­fonyl­amino)­ethyl­thio]­phenoxy­acet­amide

≥98% (HPLC), solid

Synonyme(s) :

PEPA

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About This Item

Formule empirique (notation de Hill):
C16H16N2O4S2F2
Numéro CAS:
141286-78-4
Poids moléculaire :
402.44
Numéro MDL:
MFCD04974493
Code UNSPSC :
12352200
ID de substance PubChem :
24278571
Nomenclature NACRES :
NA.77

Pureté

≥98% (HPLC)

Forme

solid

Conditions de stockage

protect from light

Couleur

white

Solubilité

DMSO: >20 mg/mL

Chaîne SMILES 

NC(=O)COc1c(F)cc(SCCNS(=O)(=O)c2ccccc2)cc1F

InChI

1S/C16H16F2N2O4S2/c17-13-8-11(9-14(18)16(13)24-10-15(19)21)25-7-6-20-26(22,23)12-4-2-1-3-5-12/h1-5,8-9,20H,6-7,10H2,(H2,19,21)

Clé InChI

GTACSIONMHMRPD-UHFFFAOYSA-N

Informations sur le gène

human ... GRIA1(2890) , GRIA2(2891) , GRIA3(2892) , GRIA4(2893)

Actions biochimiques/physiologiques

2,6-Difluoro-4-[2-(phenylsul­fonyl­amino)­ethyl­thio]­phenoxy­acet­amide is a structurally novel, selective, high affinity AMPA ionotropic glutamate receptor agonist that reduces ischemia-induced performance deficits in rats.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

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Amirbek Bekeshev et al.
Polymers, 12(7) (2020-07-02)
The conducted studies have proven the possibility of the directed control of operational properties of epoxy composites, due to the addition of finely-ground ocher into their composition, and the use of microwave modification of the epoxy composition. The rational content
Weisheng Chen et al.
Neuroscience letters, 612, 126-131 (2015-12-08)
Infralimbic cortex (IL) is proposed to suppress cocaine seeking after extinction, but whether the IL regulates the extinction and reinstatement of heroin-seeking behavior is unknown. To address this issue, the male SD rats were trained to self-administer heroin under a
Quan-Guang Zhang et al.
Hippocampus, 20(1), 65-77 (2009-03-31)
alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs) are responsible for excitotoxicity induced by ischemic injury in hippocampal CA1 neurons, whereas the molecular mechanisms responsible for their neurotrophic activities are much less studied. Here, we examined the neuroprotective effect of positive modeulation of AMPARs
Yanchao Xu et al.
Journal of colloid and interface science, 565, 23-34 (2020-01-14)
Nanofiltration (NF) membranes with tannic acid (TA) based selective layers have been intensively studied in recent years, but they still suffer from poor inorganic salt rejection. This study provided a first report on mussel-inspired co-deposition of TA and amine to
Mary L Huff et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 40(4), 861-873 (2014-09-27)
Recent findings suggest that the mesolimbic dopamine neurons, known to promote cocaine-seeking behavior, are strongly inhibited by a newly characterized region of the midbrain known as the rostromedial tegmental nucleus (RMTg). The RMTg appears to be involved in generating reward-prediction
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