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D1156

N,N-Dimethylglycine

Name: <I>N</I>,<I>N</I>-Dimethylglycine
Brand: SIGMA

≥99%, suitable for ligand binding assays

Synonyme(s) :

(Dimethylamino)acetic acid

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About This Item

Formule linéaire :

(CH₃)₂NCH₂COOH

Numéro CAS:

1118-68-9

Poids moléculaire :

103.12

Numéro Beilstein :

1700261

Numéro CE :

214-267-8

Numéro MDL:

MFCD00004283

Code UNSPSC :

12352209

eCl@ss :

32160406

ID de substance PubChem :

24893366

Nomenclature NACRES :

NA.26

product name

N,N-Dimethylglycine, ≥99%

Pureté

≥99%

Forme

powder

Technique(s)

ligand binding assay: suitable

Couleur

white to off-white

Pf

178-182 °C (lit.)

Application(s)

peptide synthesis

Chaîne SMILES

CN(C)CC(O)=O

InChI

1S/C4H9NO2/c1-5(2)3-4(6)7/h3H2,1-2H3,(H,6,7)

Clé InChI

FFDGPVCHZBVARC-UHFFFAOYSA-N

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Actions biochimiques/physiologiques

N,N-Dimethylglycine (DMG) is a natural N-methylated glycine that is used in comparative analysis with other N-methylated glycines such as sarcosine and βine. N,N-Dimethylglycine is used in the development of glycine-based ionic liquids and emulsifiers. N,N-Dimethylglycine is potentially useful as a biomarker of protein degradation in COPD patients. DMG is used as a substrate to identify, differentiate and characterize amino acid methyltransferase(s).

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

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Metabolic profiling detects biomarkers of protein degradation in COPD patients.

Baljit K Ubhi et al.

The European respiratory journal, 40(2), 345-355 (2011-12-21)

There is a paucity of biomarkers for chronic obstructive pulmonary disease (COPD). Metabolomics were applied to a defined COPD patient cohort from the ECLIPSE study (Evaluation of COPD Longitudinally to Identify Predictive Surrogate End-points). Results were correlated with accepted biomarkers

Defect in dimethylglycine dehydrogenase, a new inborn error of metabolism: NMR spectroscopy study.

S H Moolenaar et al.

Clinical chemistry, 45(4), 459-464 (1999-04-02)

A38-year-old man presented with a history of fish odor (since age 5) and unusual muscle fatigue with increased serum creatine kinase. Our aim was to identify the metabolic error in this new condition. We used 1H NMR spectroscopy to study

Cloning of dimethylglycine dehydrogenase and a new human inborn error of metabolism, dimethylglycine dehydrogenase deficiency.

B A Binzak et al.

American journal of human genetics, 68(4), 839-847 (2001-03-07)

Dimethylglycine dehydrogenase (DMGDH) (E.C. number 1.5.99.2) is a mitochondrial matrix enzyme involved in the metabolism of choline, converting dimethylglycine to sarcosine. Sarcosine is then transformed to glycine by sarcosine dehydrogenase (E.C. number 1.5.99.1). Both enzymes use flavin adenine dinucleotide and

Betaine and secondary events in an acute coronary syndrome cohort.

Michael Lever et al.

PloS one, 7(5), e37883-e37883 (2012-06-01)

Betaine insufficiency is associated with unfavourable vascular risk profiles in metabolic syndrome patients. We investigated associations between betaine insufficiency and secondary events in acute coronary syndrome patients. Plasma (531) and urine (415) samples were collected four months after discharge following

Tolerance and safety evaluation of N,N-dimethylglycine, a naturally occurring organic compound, as a feed additive in broiler diets.

Isabelle D Kalmar et al.

The British journal of nutrition, 107(11), 1635-1644 (2011-09-21)

N,N-Dimethylglycine (DMG) is a tertiary amino acid that naturally occurs as an intermediate metabolite in choline-to-glycine metabolism. The objective of the present trial was to evaluate tolerance, safety and bioaccumulation of dietary DMG in broilers when supplemented at 1 g

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