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C5851

Sigma-Aldrich

CGP 35348 hydrate

≥97% (NMR), solid

Synonyme(s) :

(3-Aminopropyl)(diethoxymethyl)phosphinic acid hydrate

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About This Item

Formule empirique (notation de Hill):
C8H20NO4P · xH2O
Numéro CAS:
123690-79-9
Poids moléculaire :
225.22 (anhydrous basis)
Numéro MDL:
MFCD11045877
Code UNSPSC :
12352200
ID de substance PubChem :
329775103
Nomenclature NACRES :
NA.77

Pureté

≥97% (NMR)

Forme

solid

Conditions de stockage

desiccated

Couleur

white

Solubilité

H2O: >20 mg/mL

Auteur

Novartis

Température de stockage

−20°C

Chaîne SMILES 

O.CCOC(OCC)P(O)(=O)CCCN

InChI

1S/C8H20NO4P.H2O/c1-3-12-8(13-4-2)14(10,11)7-5-6-9;/h8H,3-7,9H2,1-2H3,(H,10,11);1H2

Clé InChI

SRBHGEXMDCJOMS-UHFFFAOYSA-N

Application

CGP 35348 hydrate has been used as a γ-aminobutyric acid-B (GABAB) receptor inhibitor:
  • to study its effects on intrinsic optical signal (IOS) in rat hippocampus
  • alone or in combination with sodium salicylate to study its effects on auditory responses in the rat′s dorsal cortex of rat
  • to study its effects on hepatocellular carcinoma cells (HCC)

Actions biochimiques/physiologiques

CGP 35348 is a γ-aminobutyric acid-B (GABAB) receptor antagonist. It has a higher affinity towards post-versus presynaptic receptors that can penetrate the blood-brain barrier.

Caractéristiques et avantages

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the GABAB Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Attention

Product is hygroscopic

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

GABAB receptor antagonists: from synthesis to therapeutic applications.
H Bittiger et al.
Trends in pharmacological sciences, 14(11), 391-394 (1993-11-01)
Miguel A Cortez et al.
Pediatric research, 65(5), 499-503 (2009-02-05)
Infantile spasms is a catastrophic childhood seizure disorder for which few animal models exist. Children with Down syndrome are highly susceptible to infantile spasms. The Ts65Dn mouse is a valid model for Down syndrome; therefore, we tested the hypothesis that
S E Sander et al.
Neuroscience, 162(2), 423-430 (2009-05-12)
The GABA(B) receptor (GABA(B)R) agonist baclofen is known to have a beneficial potency in patients who suffer from dystonia, a neurological syndrome characterized by involuntary co-contractions of opposing muscles. The underlying mechanisms of this movement disorder are still unclear. Previous
Pavel Mareš
Epilepsy research, 92(2-3), 125-133 (2010-09-25)
Epileptic seizures activate not only excitatory but also inhibitory systems what results in an arrest of seizures. Our recent data indicate that GABAergic inhibition plays an important role in this process in cortically elicited seizures. We started to study the
K R Delaney et al.
The European journal of neuroscience, 30(11), 2077-2088 (2010-02-05)
Synaptic responses resulting from stimulation of the main olfactory and vomeronasal (VN) nerves were measured in main and accessory olfactory bulb (AOB) of frog, Rana pipiens, to test the hypothesis that properties of these synapses would reflect the distinct differences
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