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Key Documents

C3116

Sigma-Aldrich

Anti-CXCR4 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonyme(s) :

Anti-CXC Chemokine Receptor 4

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About This Item

Numéro MDL:
MFCD01092337
Code UNSPSC :
51111800

Source biologique

rabbit

Niveau de qualité

200

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Espèces réactives

human

Technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 9-14 μg/mL

Numéro d'accès UniProt

P61073

Conditions d'expédition

dry ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... CXCR4(7852)
mouse ... Cxcr4(12767)
rat ... Cxcr4(60628)

Immunogène

synthetic peptide corresponding to the third cytoplasmic loop of human CXC chemokine receptor 4 (CXCR4), conjugated to KLH. The immunizing peptide has 100% homology with the rat and mouse gene.

Application

Anti-CXCR4 antibody produced in rabbit is suitable for immunohistochemistry of formalin-fixed, paraffin-embedded tissue sections at a working concentration of 9-14 μg/mL. It was used to stain rat bladder sections at a dilution of 1:2000, incubated overnight.

Actions biochimiques/physiologiques

CXCR4 is a cell surface receptor of the chemokine CXCL12 (SDF-1) and is involved in metastasis, hematopoiesis and immune responses. It acts with CD4 to facilitate the entry of HIV into target cells. CXCR4 has important roles in tumor initiation, proliferation, invasion and metastasis of breast cancer cells.

Forme physique

Solution in phosphate buffered saline, containing 0.1% sodium azide.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

nwg

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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M J Walters et al.
British journal of cancer, 110(5), 1179-1188 (2014-01-16)
In experimental models of glioblastoma multiforme (GBM), irradiation (IR) induces local expression of the chemokine CXCL12/SDF-1, which promotes tumour recurrence. The role of CXCR7, the high-affinity receptor for CXCL12, in the tumour's response to IR has not been addressed. We
Angelo Ferrari et al.
BMC veterinary research, 8, 27-27 (2012-03-16)
Mammary tumours frequently develop in female domestic cats being highly malignant in a large percentage of cases. Chemokines regulate many physiological and pathological processes including organogenesis, chemotaxis of inflammatory cells, as well as tumour progression and metastasization. In particular, the
Pedro L Vera et al.
PloS one, 3(12), e3898-e3898 (2008-12-11)
Macrophage migration inhibitory factor (MIF) is a pro-inflammatory cytokine involved in cystitis and a non-cognate ligand of the chemokine receptor CXCR4 in vitro. We studied whether CXCR4-MIF associations occur in rat bladder and the effect of experimental cystitis. Twenty male
Max Yan et al.
Breast cancer research : BCR, 13(2), R47-R47 (2011-04-28)
Basal-like breast cancers behave more aggressively despite the presence of a dense lymphoid infiltrate. We hypothesised that immune suppression in this subtype may be due to T regulatory cells (Treg) recruitment driven by hypoxia-induced up-regulation of CXCR4 in Treg. Immunoperoxidase
Bikash Debnath et al.
Theranostics, 3(1), 47-75 (2013-02-06)
CXCR4 is a G-protein-coupled receptor involved in a number of physiological processes in the hematopoietic and immune systems. The SDF-1/CXCR4 axis is significantly associated with several diseases, such as HIV, cancer, WHIM syndrome, rheumatoid arthritis, pulmonary fibrosis and lupus. For
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