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C2618

Sigma-Aldrich

Cytochalasine D

Ready Made Solution, from Zygosporium mansonii, 5 mg/mL in DMSO

Synonyme(s) :

Zygosporine A

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About This Item

Formule empirique (notation de Hill):
C30H37NO6
Numéro CAS:
22144-77-0
Poids moléculaire :
507.62
Numéro Beilstein :
1632828
Numéro MDL:
MFCD00077706
Code UNSPSC :
51102829
ID de substance PubChem :
329775013
Nomenclature NACRES :
NA.85

Source biologique

Zygosporium mansonii

Niveau de qualité

300

Forme

solution

Concentration

5 mg/mL in DMSO

Spectre d'activité de l'antibiotique

fungi

Mode d’action

enzyme | interferes

Conditions d'expédition

wet ice

Température de stockage

−20°C

Chaîne SMILES 

[H][C@@]12[C@H](C)C(=C)[C@@H](O)[C@@H]3\C=C\C[C@H](C)C(=O)[C@](C)(O)\C=C\[C@@H](OC(C)=O)[C@@]13C(=O)N[C@H]2Cc4ccccc4

InChI

1S/C30H37NO6/c1-17-10-9-13-22-26(33)19(3)18(2)25-23(16-21-11-7-6-8-12-21)31-28(35)30(22,25)24(37-20(4)32)14-15-29(5,36)27(17)34/h6-9,11-15,17-18,22-26,33,36H,3,10,16H2,1-2,4-5H3,(H,31,35)/b13-9+,15-14+/t17-,18+,22-,23-,24+,25-,26+,29+,30+/m0/s1

Clé InChI

SDZRWUKZFQQKKV-JHADDHBZSA-N

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Catégories apparentées

Application

Cytochalasin D are isomeric metabolites of Metarrhizium anisopliae. Cytochalasin D possesses antibiotic and antitumor activity. It also impairs maintenance of long term potentiation (LTP) of actin filaments. It is implicated in promoting conditions favorable for depolymerizing actin.

Actions biochimiques/physiologiques

Cell permeable fungal toxin; potent inhibitor of actin polymerization. Disrupts actin microfilaments and activates the p53-dependent pathways causing arrest of the cell cycle at the G1-S transition. Inhibits smooth muscle contraction. Inhibits insulin-stimulated, but not basal, transport of glucose.
Inhibiteur puissant de la polymérisation de l′actine ; rompt les microfilaments d′actine ; active les voies de signalisation dépendant de p53 ; inhibe la contraction des muscles lisses , inhibe le transport du glucose stimulé par l′insuline.

Autres remarques

Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.

Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

188.6 °F - closed cup - Solvent

Point d'éclair (°C)

87 °C - closed cup - Solvent

Équipement de protection individuelle

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Certificats d'analyse (COA)

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Sahar Javaherian et al.
Integrative biology : quantitative biosciences from nano to macro, 7(3), 298-312 (2015-01-23)
During development and in adult tissues separation of phenotypically distinct cell populations is necessary to ensure proper organization and function of tissues and organs. Various phenomena, such as differential adhesion, differential mechanical tension and cell-cell repulsion, are proposed to cause
Yi-Chin Toh et al.
Biomaterials, 50, 87-97 (2015-03-05)
Heterogeneity in human pluripotent stem cell (PSC) fates is partially caused by mechanical asymmetry arising from spatial polarization of cell-cell and cell-matrix adhesions. Independent studies have shown that integrin and E-cadherin adhesions promote opposing differentiation and pluripotent fates respectively although
Ronald S Flannagan et al.
Molecular biology of the cell, 25(9), 1511-1522 (2014-03-14)
T-cell immunoglobulin mucin protein 4 (TIM4), a phosphatidylserine (PtdSer)-binding receptor, mediates the phagocytosis of apoptotic cells. How TIM4 exerts its function is unclear, and conflicting data have emerged. To define the mode of action of TIM4, we used two distinct
C S Manning et al.
Oncogene, 34(33), 4320-4332 (2014-11-11)
The acquisition of cell motility is an early step in melanoma metastasis. Here we use intravital imaging of signalling reporter cell-lines combined with genome-wide transcriptional analysis to define signalling pathways and genes associated with melanoma metastasis. Intravital imaging revealed heterogeneous
Thomas Lanzicher et al.
Scientific reports, 5, 13388-13388 (2015-09-02)
Atomic force microscopy (AFM) cell loading/unloading curves were used to provide comprehensive insights into biomechanical behavior of cardiomyocytes carrying the lamin A/C (LMNA) D192G mutation known to cause defective nuclear wall, myopathy and severe cardiomyopathy. Our results suggested that the
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