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B5057

Sigma-Aldrich

7-Benzyloxy-4-trifluoromethylcoumarin

≥99% (HPLC), solid

Synonyme(s) :

7-BFC

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About This Item

Formule empirique (notation de Hill):
C17H11F3O3
Poids moléculaire :
320.26
Numéro MDL:
MFCD01564466
Code UNSPSC :
12161501
ID de substance PubChem :
24891807
Nomenclature NACRES :
NA.47

product name

7-Benzyloxy-4-trifluoromethylcoumarin, ≥99% (HPLC), solid

Niveau de qualité

100

Pureté

≥99% (HPLC)

Forme

solid

Température de stockage

−20°C

Chaîne SMILES 

FC(F)(F)C1=CC(=O)Oc2cc(OCc3ccccc3)ccc12

InChI

1S/C17H11F3O3/c18-17(19,20)14-9-16(21)23-15-8-12(6-7-13(14)15)22-10-11-4-2-1-3-5-11/h1-9H,10H2

Clé InChI

WVKLERKKJXUPIK-UHFFFAOYSA-N

Informations sur le gène

rat ... Maoa(29253) , Maob(25750)

Application

7-Benzyloxy-4-trifluoromethylcoumarin has been used:

  • in the SBAD2-3x-AAGLY hepatocyte-like cell (HLC) functional assay to measure the cytochrome P450 3A4 (CYP3A4)-dependent activity
  • in O-dealkylation reaction to determine the activity of CYP3A
  • to measure the activity of CYP3A-mediated 7-benzyloxy-4-trifluoromethylcoumarin O-debenzylase activity (BFCOD)

Actions biochimiques/physiologiques

Metabolized primarily by cytochrome P450 isozymes CYP1A2 and CYP3A4.

Informations légales

Supplied by Gentest Corp., U.S. Patent Nos. 6,207,404.

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H302 + H312 + H332

Classification des risques

Acute Tox. 4 Oral

Code de la classe de stockage

13 - Non Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

dust mask type N95 (US), Eyeshields, Gloves

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Jiannan Ding et al.
Chemosphere, 148, 21-31 (2016-01-23)
The aim of this study was to evaluate the interactive effects of fluoxetine (FLU), roxithromycin (ROX) and propranolol (PRP) on the bioaccumulation and biochemical responses in the crucian carp Carassius auratus. After 7 days of binary exposure (ROX + FLU
Vamshi K Manda et al.
Phytotherapy research : PTR, 31(12), 1935-1945 (2017-10-27)
Kratom (Mitragyna speciosa), a native herb of Southeast Asia, is widely known for its psychoactive properties. Recent increase in the use of kratom as a recreational drug has increased the risk of its interaction with conventional drugs if taken concomitantly.
Jiannan Ding et al.
Environmental pollution (Barking, Essex : 1987), 238, 1-9 (2018-03-13)
While the presence of microplastics (MPs) in marine environments has been detected worldwide, the importance of MPs pollution in freshwater environments has also been emphasized in recent years. However, the body of knowledge regarding the biological effects of MPs on
Guanghua Lu et al.
International journal of environmental research and public health, 15(11) (2018-11-02)
2-Ethylhexyl-4-dimethylaminobenzoate (EHDAB) is a commonly used organic ultraviolet filter. The bioaccumulation and biomagnification of EHDAB were investigated in two aquatic animals, the larvae of midge (Chironomus riparius) and crucian carp (Carassius carassius), and the metabolic enzyme responses in fish liver
Vamshi K Manda et al.
Xenobiotica; the fate of foreign compounds in biological systems, 46(2), 117-125 (2015-08-08)
1. Aegle marmelos (bael) is a popular tree in India and other Southeast Asian countries. The fruit is usually consumed as dried, fresh or juice, and is reported to have a high nutritional value and many perceived health benefits. Despite its
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