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A2900

Sigma-Aldrich

[Val5]-Angiotensin II acetate salt hydrate

≥95% (HPLC), powder

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About This Item

Formule empirique (notation de Hill):
C49H69N13O12 · xC2H4O2 · yH2O
Poids moléculaire :
1032.15 (anhydrous free base basis)
Code UNSPSC :
12352209
ID de substance PubChem :
329770803

Niveau de qualité

200

Pureté

≥95% (HPLC)

Forme

powder

Composition

acetate, 1.2-10.4%

Température de stockage

−20°C

Chaîne SMILES 

O.CC(O)=O.CC(C)[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](N)CC(O)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N3CCC[C@H]3C(=O)N[C@@H](Cc4ccccc4)C(O)=O

InChI

1S/C49H69N13O12.C2H4O2.H2O/c1-26(2)39(60-42(67)33(12-8-18-54-49(51)52)56-41(66)32(50)23-38(64)65)45(70)57-34(20-29-14-16-31(63)17-15-29)43(68)61-40(27(3)4)46(71)58-35(22-30-24-53-25-55-30)47(72)62-19-9-13-37(62)44(69)59-36(48(73)74)21-28-10-6-5-7-11-28;1-2(3)4;/h5-7,10-11,14-17,24-27,32-37,39-40,63H,8-9,12-13,18-23,50H2,1-4H3,(H,53,55)(H,56,66)(H,57,70)(H,58,71)(H,59,69)(H,60,67)(H,61,68)(H,64,65)(H,73,74)(H4,51,52,54);1H3,(H,3,4);1H2/t32-,33-,34-,35-,36-,37-,39-,40-;;/m0../s1

Clé InChI

INQPQDZJLFYCRH-AXOAQIBVSA-N

Informations sur le gène

human ... AGTR1(185)
mouse ... AGTR1(11607)
rat ... AGTR1(24180)

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Amino Acid Sequence

Asp-Arg-Val-Tyr-Val-His-Pro-Phe

Description générale

[Val5]-Angiotensin II ([Val5]-ANG II) is an ANG II analog containing valine as the fifth amino acid in place of isoleucine in an ANG II octapeptide.

Application

[Val5]-Angiotensin II acetate salt hydrate has been used to induce:
  • renal damage in mice to study the role of human liver-type fatty acid-binding protein (hL-FABP)
  • vascular inflammation in mice to study the interaction of cytosolic copper chaperone antioxidant-1 (Atox1) with tumor necrosis factor (TNF)-receptor-associated factor 4 (TRAF4)
  • abdominal aortic aneurysm (AAA) in mice to study the role of vascular ATPase copper transporting α (ATP7α)

Actions biochimiques/physiologiques

[Val5]-Angiotensin II acts as an agonist for the angiotensin II type 1 receptor (AT1 receptor).

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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L X Zou et al.
American journal of hypertension, 11(5), 570-578 (1998-06-20)
Previous studies have demonstrated that augmentation of intrarenal angiotensin II (ANG II) levels during ANG II induced hypertension involves both endogenous formation and accumulation of circulating ANG II. The present work extends these findings and determines whether accumulation of infused
H Fujioka et al.
The Tohoku journal of experimental medicine, 177(3), 183-192 (1995-11-01)
We investigated the degradation of angiotensin II by vascular endothelial cells and smooth muscle cells in vitro. When angiotensin II was incubated with confluent culture of endothelial cells or with serum free conditioned medium of the endothelial cells, angiotensin II
Archita Das et al.
American journal of physiology. Cell physiology, 317(6), C1161-C1171 (2019-09-26)
NADPH oxidase (NOX)-derived reactive oxygen species (ROS) and copper (Cu), an essential micronutrient, have been implicated in vascular inflammatory diseases. We reported that in proinflammatory cytokine TNF-α-stimulated endothelial cells (ECs), cytosolic Cu chaperone antioxidant-1 (Atox1) functions as a Cu-dependent transcription
D G Butler et al.
Archives internationales de pharmacodynamie et de therapie, 329(2), 272-282 (1995-03-01)
Pressor responses to [Ile5]-Angiotensin II and [Val5]-Angiotensin II were measured following single intravenous doses of 0.0075, 0.075, 0.375, 0.75 and 7.5 micrograms/kg b.w. in anesthetised rats. [Val5]-Angiotensin II was significantly (10 per cent) more potent than [Ile5]-angiotensin II when log
Nicolas Pelisch et al.
Hypertension research : official journal of the Japanese Society of Hypertension, 33(2), 161-164 (2009-11-28)
The renin-angiotensin system has an important function in the regulation of blood pressure as well as in pathophysiological processes in the central nervous system. We examined the effects of the angiotensin receptor blocker candesartan (10 mg kg(-1) per day, p.o.)
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