A2612

Asiatic acid

≥98% (HPLC), from Centella asiatica

• Synonyme(s) : 2α,23-Dihydroxyursolic acid, Dammarolic acid, NSC 166063
• Formule empirique (notation de Hill): C₃₀H₄₈O₅
• Numéro CAS: 464-92-6
• Poids moléculaire : 488.70
• Numéro CE : 482-720-9
• Numéro MDL: MFCD00238541
• Code UNSPSC : 12352212
• ID de substance PubChem : 329770790
• Nomenclature NACRES : NA.25

Propriétés

• Source biologique: Centella asiatica
• Pureté: ≥98% (HPLC)
• Forme: powder
• Conditions de stockage: protect from light
• Couleur: white
• Pf: 325-330 °C (lit.)
• Solubilité: methanol: 1 mg/mL, clear, colorless
• Application(s): metabolomics; vitamins, nutraceuticals, and natural products
• Température de stockage: 2-8°C
• Chaîne SMILES: C[C@@H]1CC[C@@]2(CC[C@]3(C)C(=CC[C@@H]4[C@@]5(C)C[C@@H](O)[C@H](O)[C@@](C)(CO)[C@@H]5CC[C@@]34C)[C@@H]2[C@H]1C)C(O)=O
• InChI: 1S/C30H48O5/c1-17-9-12-30(25(34)35)14-13-28(5)19(23(30)18(17)2)7-8-22-26(3)15-20(32)24(33)27(4,16-31)21(26)10-11-29(22,28)6/h7,17-18,20-24,31-33H,8-16H2,1-6H3,(H,34,35)/t17-,18+,20-,21-,22-,23+,24+,26+,27+,28-,29-,30+/m1/s1
• Clé InChI: JXSVIVRDWWRQRT-UYDOISQJSA-N

Description

Description générale

Asiatic acid is a naturally occurring pentacyclic triterpenoid, obtained from Centella asiatica.

Application

Asiatic acid has been used in the in vitro study of its cytotoxic potential in glioblastoma cells. It has also been used for the in vivo quantitative analysis of asiatic acid in Centella asiatica L. and in vitro study of enhancement of asiatic acid yield upon using organic elicitors.

Starting material for asiatic acid derivative synthesis for use as:

• Anticancer agents
• Glycogen phosphorylase inhibitors
• Hepatoprotectants

Actions biochimiques/physiologiques

Asiatic acid has been reported to exhibit a pernicious effect on glioblastoma, breast, liver, melanoma, and colon cancers and anti-angiogenic activity. Additionally, it can cross the blood-brain barrier and cause apoptosis in human malignant glioma and hepatoma cells. Asiatic acid also effectively inhibits the Ultraviolet A modulated signal transduction pathways and thereby can be used against UVA-induced photoaging of the skin. It has been noted to show antinociceptive and anti-inflammatory properties plus inhibitory effect on neurotoxicity induced by β-amyloid and glutamate.

Asiatic acid is commonly used in wound healing. Asiatic acid has antioxidant, anti-inflammatory and neuroprotective properties.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable