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A0664

Sigma-Aldrich

4-Aminobutylphosphonic acid

≥99%

Synonyme(s) :

P-(4-aminobutyl)-phosphonic acid

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About This Item

Formule empirique (notation de Hill):
C4H12NO3P
Numéro CAS:
35622-27-6
Poids moléculaire :
153.12
Numéro MDL:
MFCD00063426
Code UNSPSC :
12352106
ID de substance PubChem :
24890444
Nomenclature NACRES :
NA.26

Niveau de qualité

100

Pureté

≥99%

Forme

powder

Couleur

white

Application(s)

detection

Chaîne SMILES 

NCCCCP(O)(O)=O

InChI

1S/C4H12NO3P/c5-3-1-2-4-9(6,7)8/h1-5H2,(H2,6,7,8)

Clé InChI

IDPXFPYGZRMMKZ-UHFFFAOYSA-N

Actions biochimiques/physiologiques

4-Aminobutylphosphonic acid, a GABA B receptor ligand, is used in studies on the regulation of prolactin (PRL) secretion and differential GABA receptor research.
4-aminobutylphosphonic acid, the phosphonic acid analogue of delta-aminovaleric acid, inhibits gamma-aminobutyric acid B (GABA-B receptor) binding without influencing either isoproterenol- or forskolin-stimulated cyclic AMP production.

Liaison

Analog of δ-aminovaleric acid

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H315,H319,H335

Classification des risques

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Organes cibles

Respiratory system

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

dust mask type N95 (US), Eyeshields, Gloves

Certificats d'analyse (COA)

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L S Wong et al.
Pharmacology, biochemistry, and behavior, 38(4), 829-835 (1991-04-01)
The application of 1.2 and 12.0 micrograms/side of the GABAA receptor agonist 3-aminopropane sulphonic acid bilaterally into the nucleus accumbens (Acb) of rats nonsignificantly depressed locomotor activity as assessed in automated Animex activity cages, while the highest dose (60 micrograms/side)
Oktay Yildirim et al.
International journal of molecular sciences, 11(3), 1162-1179 (2010-05-19)
FePt nanoparticles (NPs) were assembled on aluminum oxide substrates, and their ferromagnetic properties were studied before and after thermal annealing. For the first time, phosph(on)ates were used as an adsorbate to form self-assembled monolayers (SAMs) on alumina to direct the
H P De Koning et al.
Endocrinology, 132(2), 674-681 (1993-02-01)
The activity of many endocrine cells is regulated by gamma-aminobutyric acid (GABA). The effects of GABA are mediated by GABAA and/or GABAB receptors. While GABAB receptors in the central nervous system have now been extensively characterized, little is known of
N G Ternan et al.
FEMS microbiology letters, 184(2), 237-240 (2000-03-14)
A strain of the yeast Kluyveromyces fragilis was screened for its ability to utilize a range of synthetic and natural organophosphonate compounds as the sole source of phosphorus, nitrogen or carbon. Only 4-aminobutylphosphonate was utilized as sole nitrogen source with
R M Woodward et al.
Molecular pharmacology, 43(4), 609-625 (1993-04-01)
Poly(A)+ RNA from mammalian retina expresses bicuculline/baclofen-insensitive gamma-aminobutyric acid (GABA) receptors in Xenopus oocytes with properties similar to those of homooligomeric GABA rho 1 receptors. The pharmacological profile of these rho-like receptors was extended by measuring sensitivities to various GABAA
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