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Key Documents

82884

Sigma-Aldrich

Aldehyde Dehydrogenase from baker′s yeast

≥1 U/mg

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About This Item

Numéro CAS:
Numéro CE :
Numéro MDL:
Code UNSPSC :
12352204
Nomenclature NACRES :
NA.54

Forme

crystals
powder
solid

Niveau de qualité

Activité spécifique

≥1 U/mg

Température de stockage

−20°C

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Description générale

The family of aldehyde dehydrogenase (ALDH) includes 19 genes in human. It is localized to the nucleus, cytosol, mitochondria and endoplasmic reticulum of the cell.

Application

Aldehyde dehydrogenase from baker′s yeast has been used to measure the activity of aldehyde dehydrogenase by Tottmar′s method to determine the change in nicotinamide adenine dinucleotide (NADH) levels in serum sample. It has also been used in pyruvate decarboxylase assay.

Actions biochimiques/physiologiques

Aldehyde dehydrogenase (ALDH) is one of the important enzymes involved in the non-P450 aldehyde reduction enzyme system. It protects the cell from the effects of toxic substances. Expression of ALDH is known to increase with the severity of lung cancer. ALDH reduces the extent of cardiac ischemia, arising due to myocardial infarction or post cardiac surgery. Mutation in this gene causes Sjogren‐Larsson syndrome is one such autosomal disorder.
Aldehyde dehydrogenase catalyzes the oxidation of aldehydes into carboxylic acids.

Conditionnement

Bottomless glass bottle. Contents are inside inserted fused cone.

Définition de l'unité

1 U corresponds to the amount of enzyme which oxidizes 1 μmol acetaldehyde (Cat. No. 00070) to acetic acid per minute at pH 8.0 and 25 °C.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)


Certificats d'analyse (COA)

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Thiamine synthesis regulates the fermentation mechanisms in the fungus Aspergillus nidulans
Shimizu M, et al.
Bioscience, Biotechnology, and Biochemistry, 80(9), 1768-1775 (2016)
Effect of the mixture of Pueraria lobata and Sorbus commixta extract on the alcohol-induced hangover in rats
Hong SC, et al.
Natural Product Sciences, 21(2), 98-103 (2015)
Aldehyde dehydrogenase 1 is a tumor stem cell-associated marker in lung cancer
Jiang F, et al.
Molecular Cancer Research, 7(3), 330-338 (2009)
David W Crabb et al.
The Proceedings of the Nutrition Society, 63(1), 49-63 (2004-04-22)
Alcohol dehydrogenase (ADH) and mitochondrial aldehyde dehydrogenase (ALDH2) are responsible for metabolizing the bulk of ethanol consumed as part of the diet and their activities contribute to the rate of ethanol elimination from the blood. They are expressed at highest
Soo Rin Kim et al.
PloS one, 8(2), e57048-e57048 (2013-03-08)
Economic bioconversion of plant cell wall hydrolysates into fuels and chemicals has been hampered mainly due to the inability of microorganisms to efficiently co-ferment pentose and hexose sugars, especially glucose and xylose, which are the most abundant sugars in cellulosic

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