51797
Atto MB2 maleimide
Methylene Blue derivative, ≥90% (HPLC)
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About This Item
Code UNSPSC :
12352111
Nomenclature NACRES :
NA.32
Produits recommandés
Niveau de qualité
Pureté
≥90% (HPLC)
≥90% (degree of coupling)
Forme
solid
Fabricant/nom de marque
ATTO-TEC GmbH
λ
in ethanol (with 0.1% trifluoroacetic acid)
Absorption UV
λ: 655-661 nm Amax
Température de stockage
−20°C
Application
ATTO MB2 is a derivative of the well-known redox dye Methylene Blue. The dye can be reversibly reduced to the colorless leuko form. Upon oxidation the dye recovers and the absorption is fully restored. In common with most ATTO-labels the dye shows a high extinction coefficient. The dye is moderately hydrophilic. ATTO MB2 is a cationic dye. After coupling to a substrate the dye carries a net electrical charge of +1. Maleimides are well suited for coupling to thiol groups. This is similar to iodacetamides, but maleimides react more selectively with thiols. They do not show significant reaction with histidine or methionine. Hydrolysis of maleimides to a mixture of isomeric nonreactive maleamic acids can compete significantly with thiol modification, particularly above pH 8. Maleimides may be used for labeling of amines, which usually requires a higher pH than reaction of maleimides with thiols.
Informations légales
This product is for Research use only. In case of intended commercialization, please contact the IP-holder (ATTO-TEC GmbH, Germany) for licensing.
Code de la classe de stockage
11 - Combustible Solids
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
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Sadeghi Ramin et al.
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Aleksandra K Bruchey et al.
American journal of pharmacology and toxicology, 3(1), 72-79 (2008-01-01)
The goals of this review were to identify methylene blue (MB) as a compound that follows hormetic behavior for a wide range of effects and to address the question of what is unique about MB that could account for its
Notre équipe de scientifiques dispose d'une expérience dans tous les secteurs de la recherche, notamment en sciences de la vie, science des matériaux, synthèse chimique, chromatographie, analyse et dans de nombreux autres domaines..
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