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50020

Sigma-Aldrich

β-Glycerol phosphate disodium salt pentahydrate

≥98.0% (NT)

Synonyme(s) :

β-GP, β-glycerolphosphate, Disodium β-glycerol phosphate pentahydrate, glycerol-2-phosphate

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About This Item

Formule empirique (notation de Hill):
C3H7Na2O6P · 5H2O
Numéro CAS:
13408-09-8
Poids moléculaire :
306.11
Numéro Beilstein :
3744328
Numéro CE :
212-464-3
Numéro MDL:
MFCD00149083
Code UNSPSC :
41141710
ID de substance PubChem :
57651212
Nomenclature NACRES :
NA.25

Pureté

≥98.0% (NT)

Forme

solid

Impuretés

≤2% L-α-glycerol phosphate

Perte

26-32% loss on drying

Solubilité

H2O: 0.1 g/mL, clear, colorless

Température de stockage

2-8°C

Chaîne SMILES 

O.O.O.O.O.[Na+].[Na+].OCC(CO)OP([O-])([O-])=O

InChI

1S/C3H9O6P.2Na.5H2O/c4-1-3(2-5)9-10(6,7)8;;;;;;;/h3-5H,1-2H2,(H2,6,7,8);;;5*1H2/q;2*+1;;;;;/p-2

Clé InChI

PEMUISUYOHQFQH-UHFFFAOYSA-L

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Application

β-Glycerolphosphate (Glycerol-2-Phosphate) is used in the development of hydrogels and scaffolds that have applications in tissue engineering and cell growth and differentiation.

Actions biochimiques/physiologiques

Beta-Glycerophosphate is a classical serine-threonine phosphatase inhibitor used in kinase reaction buffers. BGP is often used in combination with other phosphatase/protease inhibitors for broad spectrum inhibition. It functions as an organic phosphate donor and has been used in culture media for mesenchymal stem cell differentiation to osteoblast-type cells. BGP is also used to buffer M17 media for Lactococcus culture in recombinant protein expression

Autres remarques

Substrate for myo-inositol-1-phosphatase from bovine brain

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificats d'analyse (COA)

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Cristiane Machado Mengatto et al.
PloS one, 6(1), e15848-e15848 (2011-01-26)
Successful dental and orthopedic implants require the establishment of an intimate association with bone tissue; however, the mechanistic explanation of how biological systems accomplish osseointegration is still incomplete. We sought to identify critical gene networks involved in osseointegration by exploring
Yung-Hsin Cheng et al.
Tissue engineering. Part A, 16(2), 695-703 (2009-09-23)
Injectable hydrogel is one of the great interests for tissue engineering and cell encapsulation. In the study, the gelatin molecules were added to the thermosensitive chitosan/beta-glycerol phosphate (C/GP) disodium salt hydrogels to form chitosan/gelatin/beta-glycerol phosphate (C/G/GP) disodium salt hydrogels which
A Sanghani-Kerai et al.
Bone & joint research, 6(6), 358-365 (2017-06-04)
Cellular movement and relocalisation are important for many physiologic properties. Local mesenchymal stem cells (MSCs) from injured tissues and circulating MSCs aid in fracture healing. Cytokines and chemokines such as Stromal cell-derived factor 1(SDF-1) and its receptor chemokine receptor type
Yoshitomo Honda et al.
Scientific reports, 3, 3420-3420 (2013-12-07)
Stem cell-based disease modeling presents unique opportunities for mechanistic elucidation and therapeutic targeting. The stable induction of fate-specific differentiation is an essential prerequisite for stem cell-based strategy. Bone morphogenetic protein 2 (BMP-2) initiates receptor-regulated Smad phosphorylation, leading to the osteogenic
Hideharu Okamoto et al.
PloS one, 7(8), e43800-e43800 (2012-09-01)
BACKGOROUND: MicroRNAs (miRNAs), which regulate biological processes by annealing to the 3'-untranslated region (3'-UTR) of mRNAs to reduce protein synthesis, have been the subject of recent attention as a key regulatory factor in cell differentiation. The effects of some miRNAs
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