356M-1

Cytokeratin 5 & 6 (D5 & 16B4) Mouse Monoclonal Antibody

• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.41

Propriétés

• Source biologique: mouse
• Niveau de qualité: 100; 500
• Conjugué: unconjugated
• Forme d'anticorps: culture supernatant
• Type de produit anticorps: primary antibodies
• Clone: D5 & 16B4, monoclonal
• Description: For In Vitro Diagnostic Use in Select Regions (See Chart)
• Forme: buffered aqueous solution
• Espèces réactives: human
• Conditionnement: vial of 0.1 mL concentrate (356M-14); vial of 0.5 mL concentrate (356M-15); bottle of 1.0 mL predilute (356M-17); vial of 1.0 mL concentrate (356M-16); bottle of 7.0 mL predilute (356M-18)
• Fabricant/nom de marque: Cell Marque^™
• Technique(s): immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:200
• Isotype: IgG1
• Contrôle: mesothelioma
• Conditions d'expédition: wet ice
• Température de stockage: 2-8°C
• Visualisation: cytoplasmic
• Informations sur le gène: human ... KRT5(3852)

Description

Description générale

Anti-CK 5 & 6 positivity is seen in 65% to 100% of epithelioid mesotheliomas, in 0% to 19% of lung adenocarcinomas, and in 22% to 80% of serous carcinoma of the ovary and peritoneum. Keratin 5 & 6 expression in lung adenocarcinoma is not common, and when it occurs, the reaction is usually confined to small focal areas or scattered cells. The most probable cause of this finding is the presence of squamous differentiation of lung adenocarcinoma. Anti-CK 5 & 6 positivity has been useful in recognizing squamous cell carcinoma of the skin. Less than 10% of carcinomas of the breast, colon, and prostate stain positively for this marker. Anti-CK 5 & 6 has also been used successfully as a myoepithelial cell marker in the prostate and breast to determine malignancy. Anti-CK 5 & 6 is a useful marker to distinguish lung squamous cell carcinoma from lung adenocarcinoma and large cell carcinoma within a panel including antibodies against TTF-1, Napsin A, p63, SOX-2, desmocollin3, and desmoglein3.

Qualité

IVD

IVD

IVD

RUO

Liaison

Cytokeratin 5 & 6 Positive Control Slides, Product No. 356S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Forme physique

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Notes préparatoires

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Autres remarques

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Informations légales

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany