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Merck
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Key Documents

234A-1

Sigma-Aldrich

hCG Rabbit Polyclonal Antibody

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Niveau de qualité

100
500

Conjugué

unconjugated

Forme d'anticorps

Ig fraction of antiserum

Type de produit anticorps

primary antibodies

Clone

polyclonal

Description

For In Vitro Diagnostic Use in Select Regions (See Chart)

Forme

buffered aqueous solution

Espèces réactives

human

Conditionnement

vial of 0.1 mL concentrate (234A-14)
vial of 0.5 mL concentrate (234A-15)
bottle of 1.0 mL predilute (234A-17)
vial of 1.0 mL concentrate (234A-16)
bottle of 7.0 mL predilute (234A-18)

Fabricant/nom de marque

Cell Marque™

Technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:250

Contrôle

placenta

Conditions d'expédition

wet ice

Température de stockage

2-8°C

Visualisation

cytoplasmic

Informations sur le gène

human ... NUP42(11097)

Description générale

Human chorionic gonadotropin (hCG) is a hormone synthesized by syncytiotrophoblasts and belongs to a group of glycoprotein hormones known as gonadotropins. Gonadotropins regulate normal growth, sexual development, and reproductive function. This antibody detects syncytiotrophoblasts in placenta and in tumors such as choriocarcinoma and some cases of seminoma.
hCG is a protein secreted in large quantities by normal trophoblasts; the antibody detects cells and tumors of trophoblastic origin such as choriocarcinoma. Large cell carcinoma and adenocarcinoma of the lung demonstrate anti-hCG positivity in 90% and 60% of cases respectively. 20% of lung squamous cell carcinomas are positive for anti-hCG. hCG expression by non-trophoblastic tumors may indicate aggressive behavior since it has been observed that hCG may play a role in the host response to a given tumor.

Qualité


IVD
IVD
IVD
RUO

Liaison

hCG Positive Control Slides, Product No. 234S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Forme physique

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Notes préparatoires

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Autres remarques

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Informations légales

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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Consulter la Bibliothèque de documents

L D Boucher et al.
Human pathology, 26(11), 1201-1206 (1995-11-01)
The authors studied the expression of trophoblastic cell markers in lung carcinomas cells by immunoperoxidase staining using antibodies against three trophoblastic glycoproteins (human chorionic gonadotropin [hCG]; human placental lactogen [hPL]; pregnancy-specific beta 1-glycoprotein [SP-1]). One hundred five tissue sections from
R J Kurman et al.
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists, 3(1), 101-121 (1984-01-01)
This report presents preliminary observations on the immunocytochemical localization of human chorionic gonadotropin (hCG) and human placental lactogen (hPL) in placental site trophoblastic tumors, hydatidiform moles, and choriocarcinomas and compares the findings with those of a similar immunocytochemical analysis of
Choriogonadotropin positive seminoma-a clinicopathological and molecular genetic study of 15 cases.
Hes, Ondrej et al
Annals of diagnostic pathology, 18,2, 89-94 (2014)
W L Davis et al.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 35(1), 39-48 (1987-01-01)
The calcium-regulating enzyme calcium adenosine triphosphatase (Ca-ATPase) was localized in the epithelium of amphibian urinary bladder by the one-step electron microscopic cytochemical procedure. The enzyme was identified along the basolateral border of the epithelial cells that comprise the bladder mucosa.
Determination of biological activity of gonadotropins hCG and FSH by Forster resonance energy transfer based biosensors.?
Mazina, Olga et al.
Scientific Reports, 7, 42219-42219 (2017)
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