319988

Chloroforme

contains ethanol as stabilizer, ACS reagent, ≥99.8%

• Synonyme(s) : Trichlorométhane, Trichlorure de méthylidyne
• Formule empirique (notation de Hill): CHCl₃
• Numéro CAS: 67-66-3
• Poids moléculaire : 119.38
• Numéro Beilstein : 1731042
• Numéro MDL: MFCD00000826
• Code UNSPSC : 12191502
• ID de substance PubChem : 329753942
• Nomenclature NACRES : NA.21

Propriétés

• Qualité: ACS reagent
• Niveau de qualité: 200
• Densité de vapeur: 4.1 (vs air)
• Pression de vapeur: 160 mmHg ( 20 °C)
• Pureté: ≥99.8%
• Forme: liquid
• Contient: ethanol as stabilizer
• Impuretés: Acetone and aldehyde, passes test; Acid and chloride, passes test; Free chlorine (Cl), passes test; H₂SO₄, passes test
• Résidus d'évap.: ≤0.001%
• Couleur: APHA: ≤10
• Indice de réfraction: n20/D 1.445 (lit.)
• Point d'ébullition: 60.5-61.5 °C (lit.)
• Pf: −63 °C (lit.)
• Densité: 1.48 g/mL at 25 °C; 1.492 g/mL at 25 °C (lit.)
• Traces de cations: Pb: ≤0.05 ppm
• Température de stockage: room temp
• Chaîne SMILES: ClC(Cl)Cl
• InChI: 1S/CHCl3/c2-1(3)4/h1H
• Clé InChI: HEDRZPFGACZZDS-UHFFFAOYSA-N

Description

Description générale

Chloroform, a halogenated hydrocarbon, is widely used as a solvent and extractant in various manufacturing and laboratory procedures. It can be produced by the chlorination of methane or lower-chlorinated methanes. Additionally, it is employed in the production of dichlorocarbenes, α-trichloromethyl carbinols, and trichlorolithiocarbenoids.

Application

Chloroform can be used as a solvent in the:

• Enzyme-catalyzed ring-opening polymerization of ω-pentadecalactone to prepare polyesters.
• Pd-catalyzed cross-coupling reaction of acid chlorides with arylboronic acids to synthesize diaryl Ketones.
• Enantio- and diastereoselective nitro-Mannich reaction of α-aryl nitromethanes with amido sulfones to synthesize β-nitroamines.
• Diels-Alder reaction to synthesize spiro-fused dihydropyans. The hydrogen bond (CH-O) formed between chloroform and carbonyl oxygen makes the carbonyl group a stronger heterodienophile, resulting in an increased reaction rate.

Informations sur la sécurité

• Pictogrammes: GHS06,GHS08
• Mention d'avertissement: Danger
• Mentions de danger: H302,H315,H319,H331,H336,H351,H361d,H372
• Conseils de prudence: P202 - P301 + P312 - P302 + P352 - P304 + P340 + P311 - P305 + P351 + P338 - P308 + P313
• Classification des risques: Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 Oral - STOT SE 3
• Organes cibles: Central nervous system, Liver,Kidney
• Code de la classe de stockage: 6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): does not flash
• Point d'éclair (°C): does not flash