310468

Lithium chloride

ACS reagent, ≥99%

• Formule linéaire : LiCl
• Numéro CAS: 7447-41-8
• Poids moléculaire : 42.39
• Numéro CE : 231-212-3
• Numéro MDL: MFCD00011078
• Code UNSPSC : 12352302
• ID de substance PubChem : 329753626
• Nomenclature NACRES : NA.21

Propriétés

• Qualité: ACS reagent
• Niveau de qualité: 200
• Pureté: ≥99%
• Forme: crystalline powder; powder, crystals or granules
• Impuretés: ≤0.008 meq/g Titr. base; ≤0.01% insolubles
• Perte: ≤1.0% loss on drying
• pH: 6
• Pf: 605 °C (lit.)
• Traces d'anions: sulfate (SO₄^2-): ≤0.01%
• Traces de cations: Ba: ≤0.003%; Ca: ≤0.01%; Fe: ≤0.001%; K: ≤0.01%; Na: ≤0.20%; heavy metals: ≤0.002% (by ICP)
• Chaîne SMILES: [Li+].[Cl-]
• InChI: 1S/ClH.Li/h1H;/q;+1/p-1
• Clé InChI: KWGKDLIKAYFUFQ-UHFFFAOYSA-M

Description

Description générale

Lithium chloride (LiCl) is a lithium salt. It is used as a source of chloride nucleophile as well as a source of chloride ligand in chemical synthesis. LiCl is also used as a desiccant in drying air streams.

Application

Lithium chloride can be used as:      

• A source of chloride anion for the conversion of alcohols to alkyl chloride under Mitsunobu conditions.      
• An additive in the palladium-catalyzed coupling and carbonylative coupling reactions of organostannanes and vinyl triflates.      
• A reagent for the cleavage of protecting groups under mild conditions. It readily converts acetals and ketals to the corresponding carbonyl compounds.
• A reagent in the dehydrohalogenation of α-halocarbonyl compounds to α,β-unsaturated carbonyls compound in the presence of DMF.

LiCl is also used with other reagents:      

• LiCl:DIPEA (1:1 molar ratio) is used in Horner–Wadsworth–Emmons alkenation reaction.      
• LiCl:Hexamethylphosphoric triamide is used in decarboxylative alkylation and chloride displacement reactions.
• LiCl is used as an additive in solid-phase peptide synthesis because it increases resin swelling and improves the efficiencies of complex coupling steps.

Caractéristiques et avantages

• Easy to handle      
• Weak Lewis acid      
• Highly soluble in water

Autres remarques

Go to Redi-Dri^™ Product Listing 746460

Informations légales

Redi-Dri is a trademark of Sigma-Aldrich Co. LLC

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H302,H315,H319
• Conseils de prudence: P264 - P270 - P280 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Classification des risques: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2
• Code de la classe de stockage: 13 - Non Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable