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Y0000297

Mesalazine

European Pharmacopoeia (EP) Reference Standard

Synonyme(s) :

5-Aminosalicylic acid, 5-AS, 5-Amino-2-hydroxybenzoic acid, Mesalamine

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About This Item

Formule linéaire :
H2NC6H3-2-(OH)CO2H
Numéro CAS:
89-57-6
Poids moléculaire :
153.14
Numéro Beilstein :
2090421
Numéro MDL:
MFCD00007877
Code UNSPSC :
41116107
ID de substance PubChem :
329830901
Nomenclature NACRES :
NA.24

Qualité

pharmaceutical primary standard

Famille d'API

mesalamine, mesalazine

Fabricant/nom de marque

EDQM

Pf

275-280 °C (dec.) (lit.)

Application(s)

pharmaceutical (small molecule)

Format

neat

Température de stockage

2-8°C

Chaîne SMILES 

Nc1ccc(O)c(c1)C(O)=O

InChI

1S/C7H7NO3/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3,9H,8H2,(H,10,11)

Clé InChI

KBOPZPXVLCULAV-UHFFFAOYSA-N

Informations sur le gène

human ... ALOX5(240) , PPARG(5468) , PTGS1(5742) , PTGS2(5743)

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Catégories apparentées

Description générale

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

5-Aminosalicylic acid is a peroxidase substrate suitable for use in ELISA procedures. This substrate produces a soluble end product that is brown in color and can be read spectrophotometrically at 450 nm. The reaction may be stopped with 3 N NaOH and read at 550 nm.

Conditionnement

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Autres remarques

Sales restrictions may apply.

Produit(s) apparenté(s)

Réf. du produit
Description
Tarif

PHR1148

4-Aminophénol (composé K apparenté à l'acétaminophène) (Impureté K du paracétamol), Pharmaceutical Secondary Standard; Certified Reference Material

1021204

4-Aminophénol, United States Pharmacopeia (USP) Reference Standard

1633506

Sulfanilic acid, United States Pharmacopeia (USP) Reference Standard

PHR1225

3-Aminophenol, Pharmaceutical Secondary Standard; Certified Reference Material

Y0001574

Mesalazine for system suitability, European Pharmacopoeia (EP) Reference Standard

Y0001563

4-Aminophénol, European Pharmacopoeia (EP) Reference Standard

Y0001569

2-Aminophenol, European Pharmacopoeia (EP) Reference Standard

PHR1419

Sulfanilic Acid, Pharmaceutical Secondary Standard; Certified Reference Material

1392705

Mesalamine, United States Pharmacopeia (USP) Reference Standard

1026004

3-Aminophenol, United States Pharmacopeia (USP) Reference Standard

PHR1739

2-Aminophenol, Pharmaceutical Secondary Standard; Certified Reference Material

PHR1741

2-Chloro-5-nitrobenzoic acid, Pharmaceutical Secondary Standard; Certified Reference Material

BP1075

Mesalazine, British Pharmacopoeia (BP) Reference Standard

PHR9056

2-Hydroxy-5-nitrobenzoic acid, certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H315 - H317 - H319 - H335

Classification des risques

Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

Organes cibles

Respiratory system

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

No data available

Point d'éclair (°C)

No data available

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Certificats d'analyse (COA)

Lot/Batch Number

Sorry, we don't have COAs for this product available online at this time.

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Aminosalicylic acid United States Pharmacopeia (USP) Reference Standard

USP

1026401

Aminosalicylic acid

2-Aminophenol Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1739

2-Aminophenol

Sulfasalazine 97.0-101.5%

Sigma-Aldrich

S0883

Sulfasalazine

3-Aminosalicylic acid 97%

Sigma-Aldrich

255300

3-Aminosalicylic acid

4-Aminosalicylic acid 99%

Sigma-Aldrich

A79604

4-Aminosalicylic acid

Prednisone ≥98%

Sigma-Aldrich

P6254

Prednisone

Jeffrey B Raskin et al.
Gastroenterology, 147(4), 793-802 (2014-07-20)
No therapy has been proven to prevent the recurrence of diverticulitis. Mesalamine has shown efficacy in preventing relapse in inflammatory bowel disease, and there is preliminary evidence that it might be effective for diverticular disease. We investigated the efficacy of
David T Rubin et al.
Inflammatory bowel diseases, 14(2), 265-274 (2007-10-13)
A roundtable consensus meeting was held to consolidate current knowledge on the etiology of colorectal cancer in patients with inflammatory bowel disease and to review current strategies, both diagnostic and preventive, specifically addressing the role of 5-aminosalicylic acid. Specific topics
Max Karner et al.
The American journal of gastroenterology, 109(7), 1041-1051 (2014-05-07)
Phosphatidylcholine is a key component of the mucosal barrier. Treatment with modified release phosphatidylcholine aims to improve the impaired barrier function. The primary objective is to evaluate the efficacy of LT-02, a newly designed modified release phosphatidylcholine formula, in a
A M Schoepfer et al.
Alimentary pharmacology & therapeutics, 40(8), 930-937 (2014-08-26)
There is uncertain evidence of effectiveness of 5-aminosalicylates (5-ASA) to induce and maintain response and remission of active Crohn's disease (CD), and weak evidence to support their use in post-operative CD. To assess the frequency and determinants of 5-ASA use
A H Steinhart et al.
Alimentary pharmacology & therapeutics, 25(12), 1389-1399 (2007-06-02)
To evaluate the effectiveness of pH 6-/pH 7-dependent and controlled-release mesalazines in maintaining medically and surgically induced Crohn's disease remission. A systematic search identified 13 randomized controlled trials (RCTs). The rate of symptomatic relapse (Crohn's disease activity index >150, or
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