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V0033000

Valproic acid

European Pharmacopoeia (EP) Reference Standard

Synonyme(s) :

2-Propylpentanoic acid, Valproic acid

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About This Item

Formule linéaire :
(CH3CH2CH2)2CHCO2H
Numéro CAS:
99-66-1
Poids moléculaire :
144.21
Numéro MDL:
MFCD00002672
Code UNSPSC :
41116107
ID de substance PubChem :
329828882
Nomenclature NACRES :
NA.24

Qualité

pharmaceutical primary standard

Agence

EP Reference Standard

Famille d'API

valproic acid

Fabricant/nom de marque

EDQM

Indice de réfraction

n20/D 1.425 (lit.)

Point d'ébullition

220 °C (lit.)

Densité

0.9 g/mL at 25 °C (lit.)

Application(s)

pharmaceutical (small molecule)

Format

neat

Température de stockage

2-8°C

Chaîne SMILES 

CCCC(C(O)=O)CCC

InChI

1S/C8H16O2/c1-3-5-7(6-4-2)8(9)10/h7H,3-6H2,1-2H3,(H,9,10)

Clé InChI

NIJJYAXOARWZEE-UHFFFAOYSA-N

Informations sur le gène

human ... ALDH5A1(7915)

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Description générale

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Valproic acid EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Actions biochimiques/physiologiques

Anticonvulsant that also has efficacy as a mood stabilizer in bipolar disorder

Conditionnement

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Autres remarques

Sales restrictions may apply.

Pictogrammes

Health hazardCorrosionExclamation mark
GHS08,GHS05,GHS07

Mention d'avertissement

Danger

Mentions de danger

H302,H315,H318,H360FD

Classification des risques

Acute Tox. 4 Oral - Eye Dam. 1 - Repr. 1A - Skin Irrit. 2

Code de la classe de stockage

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

231.8 °F - closed cup

Point d'éclair (°C)

111 °C - closed cup

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Certificats d'analyse (COA)

Lot/Batch Number

Désolés, nous n'avons pas de COA pour ce produit disponible en ligne pour le moment.

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USP

USP

1708718

Valproic Acid Related Compound B

Valpromide ≥97% (NMR)

Sigma-Aldrich

V3640

Valpromide

Phenytoin European Pharmacopoeia (EP) Reference Standard

P1290000

Phenytoin

SAHA ≥98% (HPLC)

Sigma-Aldrich

SML0061

SAHA

Trichostatine A ≥98% (HPLC), from Streptomyces sp.

Sigma-Aldrich

T8552

Trichostatine A

Levetiracetam European Pharmacopoeia (EP) Reference Standard

Y0001253

Levetiracetam

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The Cochrane database of systematic reviews, 6(6), CD010611-CD010611 (2013-06-26)
Some antiepileptic drugs but not others are useful in clinical practice for the prophylaxis of migraine. This might be explained by the variety of actions of these drugs in the central nervous system. The present review is part of an
Ivana Rosenzweig et al.
Neuroscience and biobehavioral reviews, 36(8), 1848-1856 (2012-06-02)
Neuropsychiatric medications that directly alter the epigenome, such as valproic acid, can under certain conditions reactivate critical developmental periods and thus impact adult neuroconnectivity. In animal models valproic acid was shown to inhibit the process of postnatal myelination and to
Florence I Roullet et al.
Neurotoxicology and teratology, 36, 47-56 (2013-02-12)
Valproic acid (VPA) is both an anti-convulsant and a mood stabilizer. Clinical studies over the past 40 years have shown that exposure to VPA in utero is associated with birth defects, cognitive deficits, and increased risk of autism. Two recent
Radu M Nanau et al.
Clinical biochemistry, 46(15), 1323-1338 (2013-06-25)
Valproic acid is a widely-used first-generation antiepileptic drug, prescribed predominantly in epilepsy and psychiatric disorders. VPA has good efficacy and pharmacoeconomic profiles, as well as a relatively favorable safety profile. However, adverse drug reactions have been reported in relation with
Periyasamy Palsamy et al.
Experimental eye research, 121, 26-34 (2014-02-15)
Recent epidemiological studies confirm the prevalence of cataract in epileptic patients. Similarly, the drugs used to treat epilepsy also show the connection with increased cataract formation. In this present study, we investigated the suppression of Nrf2/Keap1 dependent antioxidant protection through
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