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PHR1304

Supelco

Hydroxyanisole butylé

Pharmaceutical Secondary Standard; Certified Reference Material

Synonyme(s) :

2(3)-t-Butyl-4-hydroxyanisole, BHA, Éther monométhylique de la 2(3)-t-butylhydroquinone, 2(3)-t-Butylhydroquinone monométhyl éther

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About This Item

Formule linéaire :
(CH3)3CC6H3(OCH3)OH
Numéro CAS:
25013-16-5
Poids moléculaire :
180.24
Numéro CE :
246-563-8
Numéro MDL:
MFCD01779059
Code UNSPSC :
41116107
Nomenclature NACRES :
NA.24

Qualité

certified reference material
pharmaceutical secondary standard

Niveau de qualité

300

Agence

traceable to Ph. Eur. B1212000
traceable to USP 1083008

Densité de vapeur

6.2 (vs air)

Famille d'API

butylhydroxyanisole

CofA (certificat d'analyse)

current certificate can be downloaded

Température d'inflammation spontanée

599 °F

Technique(s)

HPLC: suitable
gas chromatography (GC): suitable

Pf

58-60 °C (lit.)

Application(s)

pharmaceutical (small molecule)

Format

neat

Température de stockage

2-30°C

InChI

1S/C11H16O2/c1-11(2,3)9-7-8(13-4)5-6-10(9)12/h5-7,12H,1-4H3

Clé InChI

MRBKEAMVRSLQPH-UHFFFAOYSA-N

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Catégories apparentées

Description générale

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Butylated hydroxyanisole (BHA) may be used as a reference standard for the determination of the analyte in pharmaceutical creams by spectrophotometry.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Remarque sur l'analyse

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Autres remarques

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Note de bas de page

To see an example of a Certificate of Analysis for this material enter LRAB3751 in the slot below. This is an example certificate only and may not be the lot that you receive.

Produit(s) apparenté(s)

Réf. du produit
Description
Tarif

Pictogrammes

Environment
GHS09

Mentions de danger

H411

Conseils de prudence

P273 - P391 - P501

Classification des risques

Aquatic Chronic 2

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

241.9 °F - Pensky-Martens closed cup

Point d'éclair (°C)

116.6 °C - Pensky-Martens closed cup

Choose from one of the most recent versions:

Certificats d'analyse (COA)

Lot/Batch Number
LRAD2154
LRAC9831
LRAD4394
LRAB3751
LRAA9100

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If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Determination of miconazole in pharmaceutical creams using internal standard and second derivative spectrophotometry.
Wrobel K, et al.
Journal of Pharmaceutical and Biomedical Analysis, 20(1-2), 99-105 (1999)
[Modification of the processes of chemical mutagenesis and carcinogenesis by synthetic phenol antioxidants such as butylated hydroxyanisole].
K Demkowicz-Dobrzański et al.
Postepy biochemii, 38(1), 37-42 (1992-01-01)
H Verhagen et al.
Chemico-biological interactions, 80(2), 109-134 (1991-01-01)
Butylated hydroxyanisole (BHA) is a synthetic food antioxidant used to prevent oils, fats and shortenings from oxidative deterioration and rancidity. This review depicts the current knowledge on BHA. The physical and chemical characteristics of BHA are summarized and its function
J Whysner et al.
Pharmacology & therapeutics, 71(1-2), 137-151 (1996-01-01)
Butylated hydroxyanisole (BHA), at high doses, has been found to induce forestomach squamous cell carcinomas in rodents, but not glandular cell or other types of neoplasms. BHA is not DNA-reactive, and the epigenetic mechanism of tumor formation involves cytotoxicity and
G M Williams
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 24(10-11), 1163-1166 (1986-10-01)
Studies on the potential genotoxicity and epigenetic effects of BHA are reviewed. BHA was not DNA-reactive, but studies showed that it did have an effect on membrane systems, blocking exchange between hepatocytes and epithelial cells. The available data strongly suggest
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