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N0750010

Nifedipine impurity A

European Pharmacopoeia (EP) Reference Standard

Synonyme(s) :

Oxidized Nifedipine, 2,6-Dimethyl-4-(2´-nitrophenyl)-3,5-pyridinecarboxylic acid dimethyl ester

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About This Item

Formule empirique (notation de Hill):
C17H16N2O6
Numéro CAS:
67035-22-7
Poids moléculaire :
344.32
Numéro MDL:
MFCD00153847
Code UNSPSC :
41116107
ID de substance PubChem :
329818456
Nomenclature NACRES :
NA.24

Qualité

pharmaceutical primary standard

Famille d'API

nifedipine

Fabricant/nom de marque

EDQM

Application(s)

pharmaceutical (small molecule)

Format

neat

Chaîne SMILES 

COC(=O)c1c(C)nc(C)c(C(=O)OC)c1-c2ccccc2[N+]([O-])=O

InChI

1S/C17H16N2O6/c1-9-13(16(20)24-3)15(14(10(2)18-9)17(21)25-4)11-7-5-6-8-12(11)19(22)23/h5-8H,1-4H3

Clé InChI

UMQHJQGNGLQJPF-UHFFFAOYSA-N

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Catégories apparentées

Description générale

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Nifedipine impurity A EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Actions biochimiques/physiologiques

CYP3A4 nifedipine metabolite. Nifedipine (parent compound) is an antianginal and antihypertensive agent.

Conditionnement

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Autres remarques

Sales restrictions may apply.

Produit(s) apparenté(s)

Réf. du produit
Description
Tarif

1463508

Nifedipine, United States Pharmacopeia (USP) Reference Standard

N0750000

Nifedipine, European Pharmacopoeia (EP) Reference Standard

1463600

Nifedipine Nitrophenylpyridine Analog, United States Pharmacopeia (USP) Reference Standard

N0750015

Nifedipine impurity B, European Pharmacopoeia (EP) Reference Standard

1463701

Nifedipine Nitrosophenylpyridine Analog, United States Pharmacopeia (USP) Reference Standard

PHR1290

Nifedipine, Pharmaceutical Secondary Standard; Certified Reference Material

BP462

Nifedipine, British Pharmacopoeia (BP) Reference Standard

BP866

Dimethyl 2,6-dimethyl-4-(2-nitrosophenyl)-3,5-pyridinedicarboxylate, British Pharmacopoeia (BP) Reference Standard

Pictogrammes

Corrosion
GHS05

Mention d'avertissement

Danger

Mentions de danger

H318

Classification des risques

Eye Dam. 1

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number

Désolés, nous n'avons pas de COA pour ce produit disponible en ligne pour le moment.

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Occurrence and measurement of nifedipine and its nitropyridine derivatives in human blood plasma.
J Dokladalova et al.
Journal of chromatography, 231(2), 451-458 (1982-09-10)
D G Waller et al.
British journal of clinical pharmacology, 18(6), 951-954 (1984-12-01)
Oral administration of nifedipine (20 and 30 mg tablets) to six volunteers was associated with a bioavailability of 0.43 and the presence of its nitropyridine analogue in the plasma. This metabolite was present in only trace amounts in samples taken
J L Born et al.
Chemical research in toxicology, 2(1), 57-59 (1989-01-01)
The primary deuterium isotope effect on Vm for the microsomal oxidation of the dihydropyridine calcium entry blocker nifedipine [4-(2-nitrophenyl)-2,6-dimethyl-3,5- bis(methoxycarbonyl)-1,4-dihydropyridine] has been measured. The magnitude of the kinetic isotope effect, 6.7, suggests that the rate-limiting step in the mechanism of
Tsai-Shin Chiang et al.
PloS one, 9(4), e94885-e94885 (2014-04-16)
Human hepatoma cell lines are commonly used as alternatives to primary hepatocytes for the study of drug metabolism in vitro. However, the phase I cytochrome P450 (CYP) enzyme activities in these cell lines occur at a much lower level than
Camille C Savary et al.
Drug metabolism and disposition: the biological fate of chemicals, 42(8), 1235-1240 (2014-05-17)
Humans are usually exposed to several pesticides simultaneously; consequently, combined actions between pesticides themselves or between pesticides and other chemicals need to be addressed in the risk assessment. Many pesticides are efficient activators of pregnane X receptor (PXR) and/or constitutive
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