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C2430000

Clotrimazole

European Pharmacopoeia (EP) Reference Standard

Synonyme(s) :

1-(o-Chloro-α,α-diphenylbenzyl)imidazole, 1-(o-Chlorotrityl)imidazole, 1-[(2-Chlorophenyl)diphenylmethyl]-1H-imidazole

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About This Item

Formule empirique (notation de Hill):
C22H17ClN2
Numéro CAS:
23593-75-1
Poids moléculaire :
344.84
Numéro MDL:
MFCD00057220
Code UNSPSC :
41116107
ID de substance PubChem :
329775002
Nomenclature NACRES :
NA.24

Qualité

pharmaceutical primary standard

Famille d'API

clotrimazole

Fabricant/nom de marque

EDQM

Application(s)

pharmaceutical (small molecule)

Format

neat

Chaîne SMILES 

Clc1ccccc1C(c2ccccc2)(c3ccccc3)n4ccnc4

InChI

1S/C22H17ClN2/c23-21-14-8-7-13-20(21)22(25-16-15-24-17-25,18-9-3-1-4-10-18)19-11-5-2-6-12-19/h1-17H

Clé InChI

VNFPBHJOKIVQEB-UHFFFAOYSA-N

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Description générale

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Clotrimazole EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Conditionnement

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Autres remarques

Sales restrictions may apply.

Produit(s) apparenté(s)

Réf. du produit
Description
Tarif

1141024

Clotrimazole related compound A, United States Pharmacopeia (USP) Reference Standard

PHR1183

2-Chlorobenzophenone, Pharmaceutical Secondary Standard; Certified Reference Material

1141002

Clotrimazole, United States Pharmacopeia (USP) Reference Standard

Y0000849

Clotrimazole for peak identification, European Pharmacopoeia (EP) Reference Standard

Y0000818

Clotrimazole impurity E, European Pharmacopoeia (EP) Reference Standard

BP379

Clotrimazole, British Pharmacopoeia (BP) Reference Standard

BP079

2-Chlorotritanol, British Pharmacopoeia (BP) Reference Standard

PHR2700

Clotrimazole Related Compound A, Pharmaceutical Secondary Standard; Certified Reference Material

PHR3005

Clotrimazole Impurity F, pharmaceutical secondary standard, certified reference material

Pictogrammes

Exclamation markEnvironment
GHS07,GHS09

Mention d'avertissement

Warning

Mentions de danger

H302,H315,H319,H410

Classification des risques

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

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Certificats d'analyse (COA)

Lot/Batch Number

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Sigma-Aldrich

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P W Lücker et al.
Dermatologica, 169 Suppl 1, 51-55 (1984-01-01)
The retention time and the extent of penetration in human skin of [14C] labelled bifonazole in comparison to [14C] labelled clotrimazole were investigated in 8 healthy volunteers. In the course of the investigation the backs of the volunteers were treated
Maria F Sassano et al.
Journal of medicinal chemistry, 56(6), 2406-2414 (2013-02-27)
Colloidal aggregation is the dominant mechanism for artifactual inhibition of soluble proteins, and controls against it are now widely deployed. Conversely, investigating this mechanism for membrane-bound receptors has proven difficult. Here we investigate the activity of four well-characterized aggregators against
Natalia Mast et al.
Molecular pharmacology, 84(1), 86-94 (2013-04-23)
Although there are currently three generations of antifungal azoles on the market, even the third-generation agents show undesirable interactions with human cytochrome P450 (P450) enzymes. CYP46A1 is a cholesterol-metabolizing P450 in the brain that tightly binds a number of structurally
Laura Ravani et al.
International journal of pharmaceutics, 454(2), 695-702 (2013-06-25)
The aim of the present work is to design a new formulation containing clotrimazole (CTZ) loaded into nanostructured lipid carriers (NLC) for the treatment of fungal vaginal infections. In order to obtain formulations with suitable viscosity for mucosal application, NLC
Jenna Corcoran et al.
Aquatic toxicology (Amsterdam, Netherlands), 152, 57-65 (2014-04-15)
Clotrimazole (CTZ) is a persistent imidazole antifungal agent which is frequently detected in the aquatic environment and predicted to bio-concentrate in fish. Common carp (Cyprinus carpio) were exposed to mean measured concentrations of either 1.02 or 14.63μgl(-1) CTZ for 4
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