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Autres documents

73529

Supelco

Clobetasol

≥95.0% (HPLC), pharmaceutical impurity standard

Synonyme(s) :

Clobetasol propionate impurity G (PhEur), (11β,16β)-21-Chloro-9-fluoro-11,17-dihydroxy-16-methylpregna-1,4-diene-3,20-dione

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About This Item

Formule empirique (notation de Hill):
C22H28ClFO4
Numéro CAS:
25122-41-2
Poids moléculaire :
410.91
Numéro CE :
246-633-8
Numéro MDL:
MFCD03695616
Code UNSPSC :
41116107
ID de substance PubChem :
329763802

Qualité

analytical standard

Pureté

≥95.0% (HPLC)

Durée de conservation

limited shelf life, expiry date on the label

Technique(s)

HPLC: suitable
gas chromatography (GC): suitable

Impuretés

≤10.0% related substances
≤5.0% solvents
≤5.0% water

Application(s)

pharmaceutical (small molecule)

Format

neat

Température de stockage

2-8°C

Chaîne SMILES 

C[C@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CCl

InChI

1S/C22H28ClFO4/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,24)17(26)10-20(16,3)22(12,28)18(27)11-23/h6-7,9,12,15-17,26,28H,4-5,8,10-11H2,1-3H3/t12-,15-,16-,17-,19-,20-,21-,22-/m0/s1

Clé InChI

FCSHDIVRCWTZOX-DVTGEIKXSA-N

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

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Certificats d'analyse (COA)

Lot/Batch Number
BCBS7533V
BCBR2508V
BCBP5329V
BCBM8380V
BCBL7144V

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

S Yawalkar et al.
Journal of the American Academy of Dermatology, 25(6 Pt 2), 1137-1144 (1991-12-01)
Both halobetasol propionate and clobetasol 17-propionate exerted very marked antiinflammatory, antiproliferative, and vasoconstrictive effects during evaluation in a range of dermatopharmacologic models. Halobetasol propionate was distinctly more potent than clobetasol 17-propionate in the ultraviolet-induced dermatitis inhibition assay in guinea pigs
Kai-Li Mao et al.
Colloids and surfaces. B, Biointerfaces, 160, 704-714 (2017-10-17)
A poor percutaneous penetration capability for most topical anti-inflammatory drugs is one of the main causes compromising their therapeutic effects on psoriatic skin. Even though curcumin has shown a remarkable efficacy in the treatment of psoriasis, its effective penetration through
Tina Bhutani et al.
The Journal of dermatological treatment, 23(1), 11-15 (2011-01-25)
Clobetasol 0.05% spray, a topical clobetasol propionate, is a non-greasy formulation that has shown increased clinical efficacy in a head-to-head comparison with foam formulation. Moreover, available data from randomized, controlled, double-blind trials suggests that clobetasol spray is, in fact, slightly
E A Olsen et al.
Journal of the American Academy of Dermatology, 15(2 Pt 1), 246-255 (1986-08-01)
Clobetasol-17-propionate, the most potent of currently available topical steroids as predicted by the vasoconstrictor assay, has just been approved in the United States. In psoriasis, it has proved significantly more effective than class II steroids and as or more effective
O Yélamos et al.
Journal of the European Academy of Dermatology and Venereology : JEADV, 35(1), 143-149 (2020-05-05)
Treatment response for psoriasis is typically evaluated using clinical scores. However, patients can relapse after clinical clearance, suggesting persistent inflammation. Dermoscopy, reflectance confocal microscopy (RCM) and optical coherence tomography (OCT) can non-invasively improve treatment response assessment. To compare the clinical
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