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Merck
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Principaux documents

MABX1911

Sigma-Aldrich

Anti-human IgM (10mg) KC

from mouse

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About This Item

Code UNSPSC :
12352203
eCl@ss :
32160702
Nomenclature NACRES :
NA.41

Source biologique

mouse

Forme d'anticorps

purified antibody

Type de produit anticorps

secondary antibodies

Clone

monoclonal

Espèces réactives

human

Technique(s)

ELISA: suitable
immunodiffusion: suitable

Isotype

IgG1

Description générale

Secondary antibody specific for Human Immunoglobulin M
Immunoglobulin M (IgM) is a highly conserved antibody in vertebrates and is expressed early during development of immune system. It is present as a pentamer in the serum and is secreted by peritoneal B cells.

Spécificité

Specific for Human IgM. No cross reactivity with human IgA, IgD, IgE or IgG.

Immunogène

corresponding to Human Human Serum IgM.

Application

Detect Human Serum IgM using this mouse monoclonal, Cat. No. MABX1911-10KC, validated for use in and ELISA and Lateral Flow Assay.
None
Research Category
Secondary & Control Antibodies

Actions biochimiques/physiologiques

Immunoglobulin M (IgM) plays a key role in engulfing the apoptotic cells. The reduction in serum IgM levels leads to increased autoimmune response and a higher risk of infections. IgM exhibits polyreactive and autoreactive functionality. A defect in IgM production is observed in X-linked agammaglobulinemia.

Qualité

Tested

Forme physique

Format: Purified
Ion-exchange chromatography
Purified mouse monoclonal in buffer containing 50 mM NaCl, 10 mM PBS, pH 8.0, 0.1 % sodium azide (NaN₃).

Stockage et stabilité

2-8°C. For long-term storage, freeze at -20°C.

Autres remarques

Concentration: Please refer to lot specific datasheet.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Consulter la Bibliothèque de documents

Protective roles of natural IgM antibodies
Gronwall C, et al.
Frontiers in immunology, 3, 66-66 (2012)
Structure and function of immunoglobulins.
Schroeder Jr HW and Cavacini L
The Journal of Allergy and Clinical Immunology, 125(2), S41-S52 (2010)
Harry W Schroeder et al.
The Journal of allergy and clinical immunology, 125(2 Suppl 2), S41-S52 (2010-03-05)
Immunoglobulins are heterodimeric proteins composed of 2 heavy and 2 light chains. They can be separated functionally into variable domains that bind antigens and constant domains that specify effector functions, such as activation of complement or binding to Fc receptors.
Michael R Ehrenstein et al.
Nature reviews. Immunology, 10(11), 778-786 (2010-10-16)
The existence of IgM has been known for more than a century, but its importance in immunity and autoimmunity continues to emerge. Studies of mice deficient in secreted IgM have provided unexpected insights into its role in several diverse processes

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